Sulbentine
Based on 1 publication(s) in Google Scholar
Sulbentine (Dibenzthione) is a thiadiazine-class antifungal agent. Sulbentine exhibits fungicidal and fungistatic activity against Trichophyton mentagrophytes. Sulbentine can be used for the research of dermatophyte infection.
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- Pureza: 99.37%
- No. CAS: 350-12-9
- Fòrmula: C17H18N2S2
- Peso molecular:314.47
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Sulbentine
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Actividad biológica
Sulbentine (0.5-3%; 2 h) kills 83% of Trichophyton mentagrophytes cfu in excised pig skin at 0.5% after 2 hours, and achieves 100% fungicidal activity at 3% after 2 hours[1].
Sulbentine (3%; 30 min) inhibits 67.12% of Trichophyton mentagrophytes growth in the upper stratum corneum and 49.37% of growth in the stratum granulosum of excised pig skin after 30 minutes of pre-incubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 350-12-9
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Appearance Solid
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Peso molecular 314.47
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Fòrmula C17H18N2S2
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Color White to light yellow
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SMILES
S=C1SCN(CC2=CC=CC=C2)CN1CC3=CC=CC=C3
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Synonyms
Dibenzthione
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
Solvente y solubilidad
DMSO : 50 mg/mL (159.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (3.97 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (540 KB)
- English - EN (540 KB)
- Français - FR (540 KB)
- Deutsch - DE (540 KB)
- Norwegian - NO (540 KB)
- Español - ES (540 KB)
- Swedish - SV (540 KB)
- Italian - IT (540 KB)
- Korean - KR (540 KB)
- Portuguese - PT (540 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1800 mL | 15.8998 mL | 31.7995 mL | 79.4988 mL |
| 5 mM | 0.6360 mL | 3.1800 mL | 6.3599 mL | 15.8998 mL | |
| 10 mM | 0.3180 mL | 1.5900 mL | 3.1800 mL | 7.9499 mL | |
| 15 mM | 0.2120 mL | 1.0600 mL | 2.1200 mL | 5.2999 mL | |
| 20 mM | 0.1590 mL | 0.7950 mL | 1.5900 mL | 3.9749 mL | |
| 25 mM | 0.1272 mL | 0.6360 mL | 1.2720 mL | 3.1800 mL | |
| 30 mM | 0.1060 mL | 0.5300 mL | 1.0600 mL | 2.6500 mL | |
| 40 mM | 0.0795 mL | 0.3975 mL | 0.7950 mL | 1.9875 mL | |
| 50 mM | 0.0636 mL | 0.3180 mL | 0.6360 mL | 1.5900 mL | |
| 60 mM | 0.0530 mL | 0.2650 mL | 0.5300 mL | 1.3250 mL | |
| 80 mM | 0.0397 mL | 0.1987 mL | 0.3975 mL | 0.9937 mL | |
| 100 mM | 0.0318 mL | 0.1590 mL | 0.3180 mL | 0.7950 mL |
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