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Vaborbactam

(Synonyms: RPX7009)
42 Cited Publications
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Based on 42 publication(s) in Google Scholar

Vaborbactam (RPX7009) is a cyclic boronic acid pharmacophore β-lactamase inhibitor.

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  • Pureza: 98.65%
  • No. CAS: 1360457-46-0
  • Fòrmula: C12H16BNO5S
  • Peso molecular:297.14
  • Almacenamiento:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Vaborbactam Chemical Structure
    Vaborbactam Chemical Structure
  • Experimental Validation Results for Vaborbactam
  • Experimental Validation Results for Vaborbactam
  • Experimental Validation Results for Vaborbactam
No. CAS: 1360457-46-0
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  • Vaborbactam Chemical Structure
    Vaborbactam Chemical Structure
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    Vaborbactam purchased from MedChemExpress. Usage Cited in: Antibiotics (Basel). 2021 Sep 14;10(9):1110. [Abstract]

    Customer Validation
     HEPES buffer or plasma samples spiked with 100 mg/L of meropenem, 100 mg/L of Vaborbactam or the mixture of them were subjected to the NDM-1 biosensor; the activity responses (mV) of the NDM-1 biosensor to each agent spiked in HEPES and the net activity response (∆mV) of the NDM-1 biosensor to each agent spiked in plasma are shown in panel.

  • 1/16

    Vaborbactam purchased from MedChemExpress. Usage Cited in: Int J Antimicrob Agents. 2021 Nov;58(5):106439. [Abstract]

    Customer Validation
     The β-lactamase L2 of S. maltophilia seemed overall the most susceptible to BLIs, with sulbactam and tazobactam lowering MICATM to 4–8 µg/mL, Vaborbactam (VAB; 0-32 μg/mL) to 2 µg/mL, and AVI and REL, the most effective BLIs, lowered MIC ATM to ≤1 µg/mL.

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    Vaborbactam purchased from MedChemExpress. Usage Cited in: J Clin Microbiol. 2020 Aug 24;58(9):e00932-20. [Abstract]

    Customer Validation
     100 μl of a Tris-HCl 20 mmol/liter lysis buffer containing 0.1 mM ZnSO4 and vaborbactam (50 μg/ml; MedChemExpress; reference no. HY-19930) in tube 5.A color change from yellow to red in tube 1 only containing water and the absence of any color change (no hydrolysis of nitrocefin) in the other tubes 2 to 5 indicate lack of carbapenemase activity but production of a noncarbapenemase β-lactamase, such as TEM-1 or CTX-M-type enzymes.

  • Vaborbactam