ALE-0540
Based on 1 Customer Validation
ALE-0540, a nonpeptidic small molecule, is a nerve growth factor receptor antagonist. ALE-0540 inhibits the binding of NGF to tyrosine kinase (Trk) A or both p75 and TrkA with IC50 values of 5.88 μM and 3.72 μM, respectively. ALE-0540 can be used to examine mechanisms leading to the development of agents for the study of pain.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.24%
- No. CAS: 234779-34-1
- Fòrmula: C14H11N3O5
- Peso molecular:301.25
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Kinase Inhibitor Library
HY-L009
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Neuronal Signaling Compound Library
HY-L013
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Protein Tyrosine Kinase Compound Library
HY-L016
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Pain-Related Compound Library
HY-L139
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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MCE Bioactive Compound Library
HY-L001V
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Anti-Brain Cancer Compound Library
HY-L188
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Protein Kinase Compound Library
HY-L196
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Actividad biológica
IC50: 5.88 μM (the binding of NGF to tyrosine kinase (Trk) A and TrkA); 3.72 μM (the binding of NGF to p75 and TrkA)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PC-12 | EC50 |
22 μM
Compound: 1; ALE-0540
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Inhibition of NGF-induced TrkA auto-phosphorylation in rat PC12 cells incubated for 15 mins by chemiluminescence based method
Inhibition of NGF-induced TrkA auto-phosphorylation in rat PC12 cells incubated for 15 mins by chemiluminescence based method
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[PMID: 27779399] |
| PC-12 | IC50 |
3.72 μM
Compound: 1
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Competitive binding against Nerve growth factor to p75-NGF receptor in PC12 cells
Competitive binding against Nerve growth factor to p75-NGF receptor in PC12 cells
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[PMID: 11931608] |
| PC-12 | IC50 |
3.72 μM
Compound: 1
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Inhibition of NGF-stimulated Trk A in PC12 cells
Inhibition of NGF-stimulated Trk A in PC12 cells
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[PMID: 11931608] |
| PC-12 | IC50 |
5.88 μM
Compound: 1; ALE-0540
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Inhibition of binding of [125I]-NGF to TrkA in rat PC12 cells incubated for 2 hrs by gamma counting method
Inhibition of binding of [125I]-NGF to TrkA in rat PC12 cells incubated for 2 hrs by gamma counting method
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[PMID: 27779399] |
Chemical Information
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No. CAS 234779-34-1
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Appearance Solid
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Peso molecular 301.25
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Fòrmula C14H11N3O5
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Color Light yellow to yellow
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SMILES
O=C1N(NCCO)C(C2=CC([N+]([O-])=O)=CC3=CC=CC1=C23)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 125 mg/mL (414.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3195 mL | 16.5975 mL | 33.1950 mL | 82.9876 mL |
| 5 mM | 0.6639 mL | 3.3195 mL | 6.6390 mL | 16.5975 mL | |
| 10 mM | 0.3320 mL | 1.6598 mL | 3.3195 mL | 8.2988 mL | |
| 15 mM | 0.2213 mL | 1.1065 mL | 2.2130 mL | 5.5325 mL | |
| 20 mM | 0.1660 mL | 0.8299 mL | 1.6598 mL | 4.1494 mL | |
| 25 mM | 0.1328 mL | 0.6639 mL | 1.3278 mL | 3.3195 mL | |
| 30 mM | 0.1107 mL | 0.5533 mL | 1.1065 mL | 2.7663 mL | |
| 40 mM | 0.0830 mL | 0.4149 mL | 0.8299 mL | 2.0747 mL | |
| 50 mM | 0.0664 mL | 0.3320 mL | 0.6639 mL | 1.6598 mL | |
| 60 mM | 0.0553 mL | 0.2766 mL | 0.5533 mL | 1.3831 mL | |
| 80 mM | 0.0415 mL | 0.2075 mL | 0.4149 mL | 1.0373 mL | |
| 100 mM | 0.0332 mL | 0.1660 mL | 0.3320 mL | 0.8299 mL |
ALE-0540 Related Classifications
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