ANT308
ANT308 is a vasoactive intestinal polypeptide (VIP receptor) antagonist. ANT308 significantly enhances the activation and proliferation of T cells. ANT308 inhibits the migration and metastasis, induces apoptosis of melanoma tumor cells by inhibiting VIP-VPAC2 signaling and reducing the expression of MCAM and N-cadherin. ANT308 can be used for the studies of acute myeloid leukemia (AML) and uveal melanoma (UVM).
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- No. CAS: 2871680-36-1
- Fòrmula: C156H261N47O40S
- Peso molecular:3467.10
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
ANT308 (1-10 μM, 48 h) significantly enhances CD69 and Ki67 expressions in CD4+ and CD8+ T cells[1].
ANT308 (0.1-10 μM, 72 h) reduces the viability of B16F10 and HT-144 cells dose-dependently[2].
ANT308 (10 μM, 72 h) decreases the proportion of cells in S phase, and induces apoptosis in B16LS9 and Mel 290 cells[2].
ANT308 (10 μM, 8 h) significantly inhibits cell migration in the B16LS9, Mel290, and HT-144 cell lines[2].
ANT308 (72 h) reduces MCAM and N-cadherin expression by inhibiting VIP-VPAC2 signaling[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:B16F10 and HT-144 cells
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Concentration:0.1, 1, 5 and 10 μM
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Incubation Time:72 h
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Result:Decreased the numbers of viable B16F10 and HT-144 cells by around 46% and 27%, respectively, compared to control cultures with 5 μM twice daily.
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Cell Line:B16LS9 and Mel 290 cells
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Concentration:10 μM
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Incubation Time:72 h
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Result:Increased percentages of apoptotic cells.
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Cell Line:B16LS9 and Mel 290 cells
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Concentration:10 μM
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Incubation Time:72 h
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Result:Decreased cells in the S phase.
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Cell Line:B16LS9, B16F10, Mel 290 cells, HT-144 cells
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Concentration:10 μM
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Incubation Time:8 h
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Result:Significantly inhibited cell migration in the B16LS9, Mel290, and HT-144 cell lines
ANT308 (100 μg/100 μL PBS, s.c., twice a day for 10 days) reduces the number and size of liver metastases of mice following intraocular or subcutaneous melanoma injection, and shows a trend toward reducing tumor volume at the primary tumor site[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:P815 cells induced AML model established in DBA/2j (H2Kd) mice[1]
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Dosage:6 nmol
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Administration:Subcutaneous injection (s.c.), once daily for 10-14 weeks
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Result:Significantly prolonged the survival period of mice and reduced the tumor burden.
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Animal Model:B16LS9 induced UVM model and B16LS9 or B16LS9 induced subcutaneous melanoma model established in female C57BL6/J mice (8-10 weeks) and NRG (NOD Rag gamma) mice (10-11 months old)[2]
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Dosage:100 μg/100 μL PBS
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Administration:Subcutaneous injection (s.c.), twice a day for 10 days
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Result:Significantly reduced the number of liver metastases. Reduced MCAM, but had no significant effect on N-cadherin expression. had no significant effect on subcutaneous tumor volume.
Chemical Information
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No. CAS 2871680-36-1
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Peso molecular 3467.10
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Fòrmula C156H261N47O40S
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SMILES
O=C(N1[C@@H](CCC1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N2[C@@H](CCC2)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCSC)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N
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Sequence
Lys-Pro-Arg-Arg-Pro-Tyr-Thr-Ser-Asp-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Leu-Ile-Leu-Asn
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Sequence Shortening
KPRRPYTSDYTRLRKQMAVKKYLNLILN
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ANT308 Related Classifications
HY-P11288 Related Classifications
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