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Referencia número: HY-163515

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Anticancer agent 207

Anticancer agent 207 (compound 10b) is a potent anticancer agent. Anticancer agent 207 bounds to the NRAS rG4 with a K_D value of 2.31 µM. Anticancer agent 207 shows cytotoxicity and decreases the expression of NRAS protein. Anticancer agent 207 shows antitumor activity.

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Fòrmula: C₂₉H₃₉FN₄O₂
Peso molecular:494.64

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Anticancer agent 207 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

NRAS rG4

2.31 μM (Kd)

Ver todos los productos específicos de isoformas Ras :

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	4.5 μM Compound: 10b	Cytotoxicity against human A-375 cells incubated for 48 hrs by MTT assay Cytotoxicity against human A-375 cells incubated for 48 hrs by MTT assay	[PMID: 38688064]
HepG2	IC₅₀	1.5 μM Compound: 10b	Cytotoxicity against human HepG2 cells incubated for 48 hrs by MTT assay Cytotoxicity against human HepG2 cells incubated for 48 hrs by MTT assay	[PMID: 38688064]
HL-60	IC₅₀	2.7 μM Compound: 10b	Cytotoxicity against human HL-60 cells incubated for 48 hrs by MTT assay Cytotoxicity against human HL-60 cells incubated for 48 hrs by MTT assay	[PMID: 38688064]
MCF7	IC₅₀	4.1 μM Compound: 10b	Cytotoxicity against human MCF7 cells incubated for 48 hrs by MTT assay Cytotoxicity against human MCF7 cells incubated for 48 hrs by MTT assay	[PMID: 38688064]
SK-MEL-2	IC₅₀	2 μM Compound: 10b	Cytotoxicity against human SK-MEL-2 cells incubated for 48 hrs by MTT assay Cytotoxicity against human SK-MEL-2 cells incubated for 48 hrs by MTT assay	[PMID: 38688064]

In Vitro

Anticancer agent 207 (48 h) shows cytotoxicity for NRAS-mutant melanoma SK-MEL-2 with an IC₅₀ value of 2.0 µM^[1].
Anticancer agent 207 (0, 0.5, 1.0 µM; 72 h) decreases the expression of NRAS protein^[1].
Anticancer agent 207 (0, 0.13, 0.25 µM; 10 days) inhibits the colony formation of SK-MEL-2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

SK-MEL-2 cells
Concentration:

0, 0.5, 1.0 µM
Incubation Time:

72 h
Result:

Decreased the expression of NRAS protein in a dose-dependent manner.

Cell Proliferation Assay^[1]

Cell Line:

MCF-7, HepG2, HL60, A375 cells
Concentration:

0-100 µM
Incubation Time:

48 h
Result:

Showed cytotoxicity with IC₅₀s of 4.1, 1.5, 2.7, 4.5 µM for MCF-7, HepG2, HL60, A375 cells, respectively.

In Vivo

Anticancer agent 207 (1 mg/kg; i.p.; every day for 21 days) inhibits tumor growth in volume and weight in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Six-week-old male BALB/C nude mice (SK-MEL-2 xenograft mouse model)^[1]
Dosage:

1 mg/kg
Administration:

I.p.; every day for 21 days
Result:

Suppressed tumor growth in volume and weight in the xenograft mouse model time-dependently.

Chemical Information

Peso molecular 494.64
Fòrmula C₂₉H₃₉FN₄O₂
SMILES

CCCCN(CCCOC1=CC=C2N=C3C4=C(OC3=C(C2=C1)NCCCN)C=CC(F)=C4)CCCC
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Jia-Wei Sun, et al. Design, synthesis, and evaluation of novel quindoline derivatives with fork-shaped side chains as RNA G-quadruplex stabilizers for repressing oncogene NRAS translation. European Journal of Medicinal Chemistry. 2024, 271(5): 116406.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias

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Anticancer agent 207

Ver todos los productos específicos de isoformas Ras