Anticancer agent 84
Anticancer agent 84 is an anticancer agent. Anticancer agent 84 represses the transcription of c-MYC by stabilizing the G-quadruplex (G4) structure. Anticancer agent 84 can be used for the research of cancer.
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- No. CAS: 2714510-72-0
- Fòrmula: C57H67N7O9
- Peso molecular:994.18
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Almacenamiento:
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Actividad biológica
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Chemical Information
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Actividad biológica
IC50: 5.0 μM (HepG2); 3.9 μM (MDA-MB-231); ＞100 μM (HBL-100)[1]
Anticancer agent 84 has cytotoxicity in cancer cells (HepG2, MDA-MB-231) and normal cells (HBL-100) with IC50 values of 5.0 μM, 3.9 μM and ＞100 μM, respectively[1].
Anticancer agent 84 displays good c-MYC G4 binding and stabilization abilities[1].
Anticancer agent 84 blocks c-MYC transcription by targeting the promoter G4, leading to c-MYC-dependent cancer cell death in triple-negative breast cancer cell MDA-MB-23[1].
Anticancer agent 84 (2 μM) significantly disrupts the binding of the three proteins (NM23-H2, BLM and DHX36) to c-MYC G4 with IC50 values of 0.16 μM, 2.3 μM and 7.0 μM, respectively[1].
Anticancer agent 84 (0-5 μM) impacts c-MYC-related events in TNBC, including proliferation, invasion, cell cycle, and apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cells
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Concentration:1.25, 2.5, 5 μM
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Incubation Time:48 h
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Result:Decreased the mRNA levels of c-MYC.
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Cell Line:MDA-MB-231 cells
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Concentration:1.25, 2.5, 5 μM
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Incubation Time:24 h
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Result:Could arrest MDA-MB-231 cells at the Sub G0 phase.
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Cell Line:MDA-MB-231 cells
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Concentration:1.25, 2.5, 5 μM
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Incubation Time:24 h
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Result:Induced early apoptosis and necrosis in MDA-MB-231 cells.
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Cell Line:MDA-MB-231 cells
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Concentration:1.25, 2.5 μM
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Incubation Time:24 h
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Result:Exhibited relatively weak effects on other genes and suppressed c-MYC transcription by targeting c-MYC G4.
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Cell Line:MDA-MB-231 cells
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Concentration:
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Incubation Time:48 h
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Result:Displayed good cytotoxicity against various cancer cells, including MDA-MB-231, MCF-7, HepG2, and SiHa and displayed less cytotoxicity against normal HBL-100 and NCM460 cells.
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Cell Line:MDA-MB-231 cells
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Concentration:1.25, 2.5, 5 μM
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Incubation Time:10 days
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Result:Exhibits good antiproliferative activity.
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Cell Line:MDA-MB-231 cells
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Concentration:1.25, 2.5, 5 μM
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Incubation Time:24 h
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Result:Obviously decreased the invasion with an IC50 value of 1.7 μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/C-nu/nu mice(female, five-week-aged, 10−12 g)[1]
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Dosage:2.5 mg/kg
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Administration:intraperitoneally, daily, for 24 days
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Result:Exhibited potent antitumor activity and could act as a c-MYC repressor in vivo.
Chemical Information
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No. CAS 2714510-72-0
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Peso molecular 994.18
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Fòrmula C57H67N7O9
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SMILES
CCN1C2=CC=C(C=C2C3=C1C=CC=C3)C4=NC(C5=CC=C(C=C5)N6CCN(CC6)C)=C(N4C7=CC=C(C=C7)OCCOCCOC8(O[C@@H]9O[C@H]([C@@H]([C@H]([C@@H]9O8)O)O)CO)C)C%10=CC=C(C=C%10)N%11CCN(CC%11)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 84 Related Classifications
HY-151471 Related Classifications
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