Antimalarial agent 26
Antimalarial agent 26 is an orally active 1,4-naphthoquinones derivative with antimalarial activities. Antimalarial agent 26 shows cytotoxicity against P. falciparum and selectivity over mammalian cell lines. Antimalarial agent 26 inhibits P. burghei induced parasitemia in vivo.
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- No. CAS: 2299199-56-5
- Fòrmula: C20H22N4O3
- Peso molecular:366.41
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | CC50 |
440.9 μM
Compound: 11
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Cytotoxicity against human HepG2 cells incubated for 24 hrs by MTT assay
Cytotoxicity against human HepG2 cells incubated for 24 hrs by MTT assay
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[PMID: 37130472] |
| Vero | CC50 |
1336 μM
Compound: 11
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Cytotoxicity against African green monkey Vero cells incubated for 24 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells incubated for 24 hrs by MTT assay
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[PMID: 37130472] |
Antimalarial agent 26 (compound 11) inhibits P. falciparum with IC50 of 2.7 μM, while shows CC50 on mammalian cells with CC50s of 440.9 μM (HepG2), and 1336 μM (Vero), respectively[1].
Antimalarial agent 26 (1000 to 15.62 μM; 2 h) shows hemolytic activity below 40% at concentrations from 250 to 15.6 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Antimalarial agent 26 (300 mg/kg; po; single dose) shows pathological lesions of hepatocellular damage in female mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female albino swiss mice[1]
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Dosage:300 mg/kg
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Administration:PO; single dose
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Result:Presented necrosis of hepatocytes in moderate to severe degrees, acidophilic cytoplasm with macro vacuoles and micro steatosis, granular degeneration and congestion of the lobular center vein and hepatic portal vein.
In the kidney, Resulted an atrophic glomerulus was observed with congested capillaries, reduction of mesangial cells and podocytes with discrete thickening of the basal membrane.
Chemical Information
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No. CAS 2299199-56-5
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Peso molecular 366.41
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Fòrmula C20H22N4O3
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SMILES
O=C1C=C(C(C2=C1C=CC=C2)=O)NCCN3N=NC(C4(CCCCC4)O)=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antimalarial agent 26 Related Classifications
HY-149939 Related Classifications
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