APL-1081
Based on 1 Customer Validation
APL-1081 (Mal-Exo-EVC-MMAE) is a component of the antibody-drug conjugate active molecule ADC. APL-1081 is formed by conjugating the ADC linker (peptide Mal-Exo-EEVC) with the potent tubulin polymerization inhibitor Monomethyl auristatin E (HY-15162). APL-1081 can be used in tumor research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.79%
- No. CAS: 2921735-80-8
- Fòrmula: C75H115N13O19
- Peso molecular:1502.79
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Almacenamiento:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
In Vitro
APL-1081 is conjugated to Trastuzumab (HY-P9907) via a tripeptide Exo-Linker to generate multi-payload ADC 2, with a DAR of 9.7 determined by RP-HPLC and an aggregation rate of 0.3% determined by SEC[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2921735-80-8
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Appearance Solid
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Peso molecular 1502.79
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Fòrmula C75H115N13O19
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Color White to off-white
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SMILES
O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OC(C3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CCC(O)=O)=O)=O)=O)C(NCCCCCN4C(C=CC4=O)=O)=O)=O)=O)=O)=O)OC)=O
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Synonyms
Mal-Exo-EVC-MMAE
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (66.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (289 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Watanabe T, et al. Exo-Cleavable Linkers: Enhanced Stability and Therapeutic Efficacy in Antibody-Drug Conjugates. Journal of medicinal chemistry. 2024 Oct 24;67(20):18124-18138. [Content Brief]
[2]. Watanabe T, et al. Homogeneous Dual-Payload Antibody-Drug Conjugates Produced by Combined Distinct Conjugation Strategies. ACS medicinal chemistry letters. 2025 Jul 10;16(7):1334-1339. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6654 mL | 3.3271 mL | 6.6543 mL | 16.6357 mL |
| 5 mM | 0.1331 mL | 0.6654 mL | 1.3309 mL | 3.3271 mL | |
| 10 mM | 0.0665 mL | 0.3327 mL | 0.6654 mL | 1.6636 mL | |
| 15 mM | 0.0444 mL | 0.2218 mL | 0.4436 mL | 1.1090 mL | |
| 20 mM | 0.0333 mL | 0.1664 mL | 0.3327 mL | 0.8318 mL | |
| 25 mM | 0.0266 mL | 0.1331 mL | 0.2662 mL | 0.6654 mL | |
| 30 mM | 0.0222 mL | 0.1109 mL | 0.2218 mL | 0.5545 mL | |
| 40 mM | 0.0166 mL | 0.0832 mL | 0.1664 mL | 0.4159 mL | |
| 50 mM | 0.0133 mL | 0.0665 mL | 0.1331 mL | 0.3327 mL | |
| 60 mM | 0.0111 mL | 0.0555 mL | 0.1109 mL | 0.2773 mL |
APL-1081 Related Classifications
HY-169322 Related Classifications
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