APL-1082
Based on 1 Customer Validation
APL-1082 is a drug-Linker conjugate that can be used for ADC synthesis. APL-1082 contains Exatecan (HY-13631) and Linker (HY-175929). APL-1082 reduces aggregation and hydrophobicity in Trastuzumab (HY-P9907) ADCs, enables production of high-DAR (10) ADCs with homogeneity and defined physicochemical properties. APL-1082 forms a Trastuzumab ADC with enhanced stability, showing greater DAR retention over time. APL-1082 can be used for the research of gastric cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 95.58%
- No. CAS: 2921735-93-3
- Fòrmula: C60H70FN11O16
- Peso molecular:1220.26
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Almacenamiento:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
APL-1082 conjugated Trastuzumab (DAR = 8) has higher hydrophilicity, shorter HIC retention time, and lower aggregation rate than Trastuzumab-deruxtecan (HY-138298A)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NOD.CB17 homozygous mice (5 × 106 NCI-N87 cells was injected into the right hind flank for a xenograft model)[1]
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Dosage:1.25 mg/kg conjugated with Trastuzumab; 2.5 mg/kg conjugated with Trastuzumab
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Administration:tail vein injection; 4 doses on days 0, 4, 7, and 11
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Result:Inhibited tumor growth.
Chemical Information
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No. CAS 2921735-93-3
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Appearance Solid
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Peso molecular 1220.26
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Fòrmula C60H70FN11O16
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Color Light yellow to yellow
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SMILES
O=C(C=CC1=O)N1CCCCCNC(C(C2=CC=C(C=C2)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CCC(O)=O)=O)=O)=O)OC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O
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Synonyms
Mc-exo-EVC-Exatecan
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvente y solubilidad
DMSO : ≥ 100 mg/mL (81.95 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (279 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8195 mL | 4.0975 mL | 8.1950 mL | 20.4874 mL |
| 5 mM | 0.1639 mL | 0.8195 mL | 1.6390 mL | 4.0975 mL | |
| 10 mM | 0.0819 mL | 0.4097 mL | 0.8195 mL | 2.0487 mL | |
| 15 mM | 0.0546 mL | 0.2732 mL | 0.5463 mL | 1.3658 mL | |
| 20 mM | 0.0410 mL | 0.2049 mL | 0.4097 mL | 1.0244 mL | |
| 25 mM | 0.0328 mL | 0.1639 mL | 0.3278 mL | 0.8195 mL | |
| 30 mM | 0.0273 mL | 0.1366 mL | 0.2732 mL | 0.6829 mL | |
| 40 mM | 0.0205 mL | 0.1024 mL | 0.2049 mL | 0.5122 mL | |
| 50 mM | 0.0164 mL | 0.0819 mL | 0.1639 mL | 0.4097 mL | |
| 60 mM | 0.0137 mL | 0.0683 mL | 0.1366 mL | 0.3415 mL | |
| 80 mM | 0.0102 mL | 0.0512 mL | 0.1024 mL | 0.2561 mL |
APL-1082 Related Classifications
HY-175888 Related Classifications
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