Arazine
Based on 1 Customer Validation
Arazine (N-Acetyl-S-farnesyl-L-cysteine) is a cell-permeable modulator of G protein and G-protein coupled receptor signaling. Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.4%
- No. CAS: 135304-07-3
- Fòrmula: C20H33NO3S
- Peso molecular:367.55
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Almacenamiento:
Solution, -20°C, 2 years
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Actividad biológica
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Actividad biológica
Descripciòn
In Vitro
Arazine (2 hours) inhibits ATPγS induced CXCL1, CXCL8 and CCL2 production as a dose-dependent manner in HMEC-1 cell[1]. Arazine (10–100 μM;8 hours) significantly affects the HMEC-1 cell viability as measured by trypan blue exclusion in HMEC-1 cell[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:TPA-induced ear acute inflammation in mouse[1]
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Dosage:2000 μg/20 μl
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Administration:2000 μg/20 μl; Applied on ear
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Result:Inhibited ear edema, as measured by ear weight.
Chemical Information
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No. CAS 135304-07-3
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Appearance Liquid
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Peso molecular 367.55
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Fòrmula C20H33NO3S
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Color Colorless to light yellow
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SMILES
O=C(O)[C@H](CSC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)NC(C)=O
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Synonyms
N-Acetyl-S-farnesyl-L-cysteine
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Solution, -20°C, 2 years
Pureza y Documentación
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Ficha de datos (266 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Gordon JS, et al. Topical N-acetyl-S-farnesyl-L-cysteine inhibits mouse skin inflammation, and unlike dexamethasone, its effects are restricted to the application site.J Invest Dermatol. 2008 Mar;128(3):643-54. Epub 2007 Sep 20. [Content Brief]
[2]. Adhami K, et al. N-acetyl-S-farnesyl-l-cysteine suppresses chemokine production by human dermal microvascular endothelial cells.Exp Dermatol. 2012 Sep;21(9):700-5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Arazine Related Classifications
HY-133021 Related Classifications
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