ARL 17477
Based on 1 publication(s) in Google Scholar
ARL-17477 is a dual inhibitor of NOS1and the autophagy-lysosomal system with anticancer activity and can inhibit tumor growth in KRAS-mutated cancers.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.02%
- No. CAS: 866914-87-6
- Fòrmula: C20H22Cl3N3S
- Peso molecular:442.83
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) ARL 17477
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Actividad biológica
Chemical Information
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No. CAS 866914-87-6
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Appearance Solid
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Peso molecular 442.83
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Fòrmula C20H22Cl3N3S
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Color Off-white to light yellow
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SMILES
[H]Cl.[H]Cl.N=C(C1=CC=CS1)NC2=CC=C(CCNCC3=CC(Cl)=CC=C3)C=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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bioRxiv
Targeting GPR183 to reduce peripheral sensitization: evidence from rodent and human tissue analyses. [Abstract]2026 Jan 16:2026.01.15.699745. PMID: 41648147
Solvente y solubilidad
DMSO : 62.5 mg/mL (141.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 20 mg/mL (45.16 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.2582 mL | 11.2910 mL | 22.5820 mL | 56.4551 mL |
| 5 mM | 0.4516 mL | 2.2582 mL | 4.5164 mL | 11.2910 mL | |
| 10 mM | 0.2258 mL | 1.1291 mL | 2.2582 mL | 5.6455 mL | |
| 15 mM | 0.1505 mL | 0.7527 mL | 1.5055 mL | 3.7637 mL | |
| 20 mM | 0.1129 mL | 0.5646 mL | 1.1291 mL | 2.8228 mL | |
| 25 mM | 0.0903 mL | 0.4516 mL | 0.9033 mL | 2.2582 mL | |
| 30 mM | 0.0753 mL | 0.3764 mL | 0.7527 mL | 1.8818 mL | |
| 40 mM | 0.0565 mL | 0.2823 mL | 0.5646 mL | 1.4114 mL | |
| DMSO | 50 mM | 0.0452 mL | 0.2258 mL | 0.4516 mL | 1.1291 mL |
| 60 mM | 0.0376 mL | 0.1882 mL | 0.3764 mL | 0.9409 mL | |
| 80 mM | 0.0282 mL | 0.1411 mL | 0.2823 mL | 0.7057 mL | |
| 100 mM | 0.0226 mL | 0.1129 mL | 0.2258 mL | 0.5646 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
ARL 17477 Related Classifications
HY-107720 Related Classifications
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