AV123
Based on 1 Customer Validation
AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor (IC50=12.12 µM). AV123 blocks the TNF-α-induced necroptotic (EC50=1.7 μM) but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart and kidney, inflammatory diseases, neurodegenerative diseases and infectious diseases.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.60%
- No. CAS: 233605-81-7
- Fòrmula: C11H14N4O2
- Peso molecular:234.25
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
IC50: 0.48 µM (CDK9/ CyclinT), 0.80 µM (CLK1 of Mus musculus), 1.80 µM (DYRK1A of Rattus norvegicus), >10 µM (CDK2/CyclinA, CDK5/p25, HASPIN, Pim1, CK1 ε, JAK3, ABL1, RIPK3, AURKB)[1].
AV123 (0.01-100 µM; 24 h) efficiently blocks necroptosis in a dose-dependent manner in FADD-deficient Jurkat cells[1].
AV123 (0.01-50 µM; 24 h) shows no toxicity to RPE-1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:FADD-deficient Jurkat cells
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Concentration:0.01-100 µM
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Incubation Time:24 h
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Result:Significantly blocked the necroptotic cell-death induced by TNF-α with an EC50 value of 1.7 µM.
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Cell Line:RPE-1 cells
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Concentration:0.01-50 µM
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Incubation Time:24 h
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Result:Exhibited no toxicity to RPE-1 cells.
Chemical Information
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No. CAS 233605-81-7
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Appearance Solid
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Peso molecular 234.25
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Fòrmula C11H14N4O2
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Color Light yellow to yellow
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SMILES
O=[N+](C1=CC=C2C(NC(NCCCC)=N2)=C1)[O-]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 200 mg/mL (853.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.2689 mL | 21.3447 mL | 42.6894 mL | 106.7236 mL |
| 5 mM | 0.8538 mL | 4.2689 mL | 8.5379 mL | 21.3447 mL | |
| 10 mM | 0.4269 mL | 2.1345 mL | 4.2689 mL | 10.6724 mL | |
| 15 mM | 0.2846 mL | 1.4230 mL | 2.8460 mL | 7.1149 mL | |
| 20 mM | 0.2134 mL | 1.0672 mL | 2.1345 mL | 5.3362 mL | |
| 25 mM | 0.1708 mL | 0.8538 mL | 1.7076 mL | 4.2689 mL | |
| 30 mM | 0.1423 mL | 0.7115 mL | 1.4230 mL | 3.5575 mL | |
| 40 mM | 0.1067 mL | 0.5336 mL | 1.0672 mL | 2.6681 mL | |
| 50 mM | 0.0854 mL | 0.4269 mL | 0.8538 mL | 2.1345 mL | |
| 60 mM | 0.0711 mL | 0.3557 mL | 0.7115 mL | 1.7787 mL | |
| 80 mM | 0.0534 mL | 0.2668 mL | 0.5336 mL | 1.3340 mL | |
| 100 mM | 0.0427 mL | 0.2134 mL | 0.4269 mL | 1.0672 mL |
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