BiP inducer X
Based on 7 publication(s) in Google Scholar
BiP inducer X, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (endoplasmic reticulum) stress inhibitor. BiP inducer X preferentially induces BiP with slight inductions of GRP94, calreticulin, and C/EBP homologous protein. BiP inducer X protects neurons from ER stress.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.62%
- No. CAS: 101714-41-4
- Fòrmula: C9H7NO3S
- Peso molecular:209.22
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Apoptosis Compound Library
HY-L003
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HY-L054
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HY-L158
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Publications Citing Use of MedChemExpress (MCE) BiP inducer X
More- Adv Sci (Weinh). 2025 Sep 26:e08991. [Abstract]
- Cell Mol Life Sci. 2024 Jan 22;81(1):49. [Abstract]
- iScience. 2023 Oct 13;26(11):108207. [Abstract]
- Neurochem Int. 2023 Oct:169:105573. [Abstract]
- Aquaculture. 2023 Jun 8, 739757.
- Virol J. 2025 Nov 17;22(1):378. [Abstract]
- Research Square Print. 2023 Mar 6.
Customer Validation & Images
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RT-PCR
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Cell Imaging/Staining
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IF
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WB
Actividad biológica
BiP inducer X (5 μM; 0-12 hours; SK-N-SH cells) increase BiP protein[1].
The induction of BiP by BiP inducer X (BIX) is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway[1].
BiP inducer X (5 μM; 12 hours; pretreatment with SK-N-SH cells) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
A 20 μg portion of BiP inducer X administration reduces ER stress-induced apoptosis induced in the penumbra by MCA occlusion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male adult ddY mice weighing 24-34 g (Japan SLC)[1]
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Dosage:20 μg (2 μl)
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Administration:Intracerebroventricularly
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Result:Significantly increased the level of BiP protein 24 h after administration, confirming that administration of BIX induces BiP protein in vivo.
Chemical Information
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No. CAS 101714-41-4
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Appearance Solid
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Peso molecular 209.22
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Fòrmula C9H7NO3S
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Color Brown to gray
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SMILES
N#CSCC(C1=CC(O)=C(O)C=C1)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (7)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Acetylation of the Mitochondrial Chaperone GRP75 Governs ER-Mitochondrial Calcium Homeostasis and Hepatocyte Insulin Resistance. [Abstract]2025 Sep 26:e08991. PMID: 41001747 -
Cell Mol Life Sci
Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc. [Abstract]2024 Jan 22;81(1):49. PMID: 38252317 -
iScience
Exploring the role of SWI/SNF complex subunit BAF60c in lipid metabolism and inflammation in fish. [Abstract]2023 Oct 13;26(11):108207. PMID: 37942006
BiP inducer X purchased from MedChemExpress. Usage Cited in: iScience. 2023 Oct 13;26(11):108207. [Abstract]
Relative mRNA expression of BAF60c and GRP78 after BiP inducer X (BiP) (1, 5, 10 μM) treatment for 4 h with different concentrations in macrophages.
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Neurochem Int
The ER chaperone, BIP protects Microglia from ER stress-mediated Apoptosis in Hyperglycemia. [Abstract]2023 Oct:169:105573. PMID: 37454816
BiP inducer X purchased from MedChemExpress. Usage Cited in: Neurochem Int. 2023 Oct:169:105573. [Abstract]
Representative bright field image of BIX (25 μM) treated cells.
BiP inducer X purchased from MedChemExpress. Usage Cited in: Neurochem Int. 2023 Oct:169:105573. [Abstract]
Immunocytochemistry analysis of BIP, Texas Red fluorescence conjugated secondary antibody was used to detect BIP and DAPI for nuclear staining in BIX (25 μM)-treated cells.
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Virol J
2025 Nov 17;22(1):378. PMID: 41250234 -
BiP inducer X purchased from MedChemExpress. Usage Cited in: Research Square Print. 2023 Mar 6.
BiP inducer X (BIX; 25 mM) significantly reduces the expression levels of pro-apoptotic marker proteins including Bax, Bad, cytochrome-C, and caspase-1 in microglia cells.
Solvente y solubilidad
DMSO : 50 mg/mL (238.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (11.95 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7797 mL | 23.8983 mL | 47.7966 mL | 119.4914 mL |
| 5 mM | 0.9559 mL | 4.7797 mL | 9.5593 mL | 23.8983 mL | |
| 10 mM | 0.4780 mL | 2.3898 mL | 4.7797 mL | 11.9491 mL | |
| 15 mM | 0.3186 mL | 1.5932 mL | 3.1864 mL | 7.9661 mL | |
| 20 mM | 0.2390 mL | 1.1949 mL | 2.3898 mL | 5.9746 mL | |
| 25 mM | 0.1912 mL | 0.9559 mL | 1.9119 mL | 4.7797 mL | |
| 30 mM | 0.1593 mL | 0.7966 mL | 1.5932 mL | 3.9830 mL | |
| 40 mM | 0.1195 mL | 0.5975 mL | 1.1949 mL | 2.9873 mL | |
| 50 mM | 0.0956 mL | 0.4780 mL | 0.9559 mL | 2.3898 mL | |
| 60 mM | 0.0797 mL | 0.3983 mL | 0.7966 mL | 1.9915 mL | |
| 80 mM | 0.0597 mL | 0.2987 mL | 0.5975 mL | 1.4936 mL | |
| 100 mM | 0.0478 mL | 0.2390 mL | 0.4780 mL | 1.1949 mL |
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