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Referencia número: HY-120433

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BLT-3

BLT-3 is an inhibitor of scavenger receptor class B type I (SR-BI) that exerts reversible, non-cell-type-specific inhibitory effects on SR-BI-mediated lipid transport. BLT-3 inhibits SR-BI-mediated selective lipid uptake from HDL as well as cholesterol efflux from cells to HDL. BLT-3 enhances the binding of HDL to SR-BI. BLT-3 is applicable to research related to atherosclerosis and coronary heart disease.

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No. CAS: 109940-24-1
Fòrmula: C₁₉H₁₃NO
Peso molecular:271.32

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Please store the product under the recommended conditions in the Certificate of Analysis.

BLT-3 Chemical Structure

No. CAS: 109940-24-1

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Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
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Actividad biológica

Descripciòn

In Vitro

BLT-3 inhibits SR-BI-mediated DiI uptake from DiI-HDL in ldlA[mSR-BI] cells, with an IC₅₀ of 0.51 μM^[1].
BLT-3 inhibits SR-BI-mediated [³H]CE uptake from [³H]CE-HDL in ldlA[mSR-BI] cells, with an IC₅₀ of 2.3 μM^[1].
BLT-3 inhibits SR-BI-mediated [³H]CE uptake from [³H]CE-HDL in Y1-BS1 cells, with an IC₅₀ of 1.7 μM^[1].
BLT-3 inhibits SR-BI-mediated [³H]cholesterol efflux to HDL in ldlA[mSR-BI] cells, with an IC₅₀ of 17.2 μM^[1].
BLT-3 enhances the binding of ¹²⁵I-HDL to SR-BI in ldlA[mSR-BI] cells by increasing binding affinity (decreasing K_d and Koff) without altering Bmax, with an IC₅₀ of 46.5 μM for its binding-enhancing effect^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 109940-24-1
Peso molecular 271.32
Fòrmula C₁₉H₁₃NO
SMILES

N=1OC(C=2C=CC=CC2)=C3C=CC=C3C1C=4C=CC=CC4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Nieland TJ, et al. Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI. Proc Natl Acad Sci U S A. 2002;99(24):15422-15427. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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