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Referencia número: HY-138154

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BLX-3887

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BLX-3887 is a selective 15-lipoxygenase type 1 (15-LO-1) inhibitor with an IC₅₀ of 32 nM. BLX-3887 can be utilized in research related to the 15-LO pathways.

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Pureza: 98.0%
No. CAS: 934758-70-0
Fòrmula: C₁₀H₅Cl₃FN₃O
Peso molecular:308.52

Almacenamiento:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

BLX-3887 Chemical Structure

No. CAS: 934758-70-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
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Bioz

Actividad biológica

Descripciòn

BLX-3887 is a selective 15-lipoxygenase type 1 (15-LO-1) inhibitor with an IC₅₀ of 32 nM. BLX-3887 can be utilized in research related to the 15-LO pathways^[1].

IC₅₀ & Target

15-LOX-1

32 nM (IC₅₀)

Ver todos los productos específicos de isoformas Lipoxygenase :

Cellular Effect

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	32 nM Compound: 3c	Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic acid substrate addition by HPLC-UV spectroscopy Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic acid substrate addition by HPLC-UV spectroscopy	[PMID: 26037322]

Chemical Information

No. CAS 934758-70-0
Appearance Solid
Peso molecular 308.52
Fòrmula C₁₀H₅Cl₃FN₃O
Color White to off-white
SMILES

O=C(C1=NNC(Cl)=C1Cl)NC2=CC=C(F)C=C2Cl
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Archambault AS, et al. Comparison of eight 15-lipoxygenase (LO) inhibitors on the biosynthesis of 15-LO metabolites by human neutrophils and eosinophils. PLoS One. 2018 Aug 17;13(8):e0202424. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
Chemical Information
Pureza y Documentación
Referencias

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BLX-3887

High-Throughput Bioactive Compound Library

Ver todos los productos específicos de isoformas Lipoxygenase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

BLX-3887 Related Classifications

HY-138154 Related Classifications