BMS-986497
Based on 1 Customer Validation
BMS-986497 (ORM-6151) is a CD33-targeting antibody-conjugated GSPT1 degrader. BMS-986497 delivers the GSPT1 degrader SMol006 to CD33-expressing cells and induces GSPT1 protein degradation. BMS-986497 shows potential for research on acute myeloid leukemia (AML).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.59%
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Almacenamiento:
-80°C
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
In Vitro
ORM-6151 (BMS-986497) (picomolar concentrations) shows picomolar cytotoxic activity in CD33-expressing AML cell lines, including Mylotarg-resistant AML193 and Kasumi6 cell lines, with 10-1000-fold greater potency than reference GSPT1 degrader molecules[1].
ORM-6151 (BMS-986497) (picomolar concentrations) shows picomolar cytotoxic potency in primary relapsed/refractory AML patient blasts, with better potency than CC-90009 and Mylotarg[1].
ORM-6151 (BMS-986497) exhibits minimal cytotoxic activity in healthy hematopoietic progenitor cells, with 10-10,000-fold less toxicity than CC-90009 or Mylotarg[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:xenograft model[1]
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Dosage:1 mg/kg
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Administration:single treatment
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Result:Demonstrated robust anti-tumor efficacy, with superior activity compared to CC-90009.
Showed tumor growth inhibition correlated with the degree and duration of GSPT1 depletion and changes in expression of integrated stress response biomarker genes.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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Appearance Liquid
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Color Colorless to light yellow
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SMILES
[BMS-986497]
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Synonyms
ORM-6151
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Envío
Shipping with dry ice.
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Almacenamiento
-80°C
Pureza y Documentación
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Ficha de datos (278 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-986497 Related Classifications
HY-171792 Related Classifications
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Keywords
- BMS-986497
- ORM-6151
- BMS986497
- BMS 986497
- ORM6151
- ORM 6151
- Antibody-Drug Conjugates (ADCs)
- Eukaryotic Release Factor (eRF)
- Transmembrane Glycoprotein
- CD33
- acute myeloid leukemia xenograft models
- myelodysplastic neoplasms
- AML193
- Kasumi6
- acute myeloid leukemia cells
- healthy hematopoietic progenitor cells
- MV4-11
- GSPT1
- primary relapsed/refractory acute myeloid leukemia blasts
- Inhibitor
- inhibitor
- inhibit