BNN6
Based on 1 publication(s) in Google Scholar
BNN6 is a thermoresponsive nitric oxide (NO) donor that often works by binding to a carrier. BNN6 decomposes under the heat stimulation generated by photothermal action, releasing high concentrations of NO, which exerts anti-tumor activity by inducing tumor cell apoptosis and inhibiting their repair. BNN6 can be used to synthesize the multifunctional biosensor BNN6-BiTiS3-iRGD, which exerts a synergistic anti-cancer effect with photothermal therapy (PTT).
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- Pureza: 98.0%
- No. CAS: 106476-75-9
- Fòrmula: C14H22N4O2
- Peso molecular:278.35
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
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Publications Citing Use of MedChemExpress (MCE) BNN6
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Actividad biológica
BNN6 (100 μg/mL; combined with laser irradiation for 5 min) significantly reduces the viability of 4T1 and MDA-MB-231 cells, inhibits cell migration, and induced apoptosis[1].
BNN6 (100 μg/mL; combined with laser irradiation for 5 min) ceffectively releases nitric oxide (NO) in 4T1 and MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:4T1 and MDA-MB-231 cells
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Concentration:100 μg/mL
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Incubation Time:5 minutes (with laser irradiation)
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Result:Significantly decreased the viability of 4T1 and MDA-MB-231 cells and markedly induced apoptosis, as evidenced by increased apoptotic rates and upregulated expression of apoptotic-related proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4T1 and MDA-MB-231 cells[1]
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Dosage:100 μg/mL
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Administration:5 minutes (with laser irradiation)
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Result:Significantly decreased the viability of 4T1 and MDA-MB-231 cells and markedly induced apoptosis, as evidenced by increased apoptotic rates and upregulated expression of apoptotic-related proteins.
Chemical Information
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No. CAS 106476-75-9
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Appearance Solid
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Peso molecular 278.35
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Fòrmula C14H22N4O2
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Color Off-white to light yellow
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SMILES
O=NN(C(C)CC)C1=CC=C(N(C(C)CC)N=O)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
2025 Jul 1;16(1):5677. PMID: 40593809
Solvente y solubilidad
DMSO : 175 mg/mL (628.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Jiang M, et al., BiTiS3 bio-transducer with explosive on-demand generation of NO gas for synergetic cancer therapy. Biosens Bioelectron. 2024 Feb 15;246:115895. [Content Brief]
[2]. Yang J, et al. Controlled Nitric Oxide-Releasing Nanovehicles for Enhanced Infected Wound Healing: A Study on PDA@BNN6 Encapsulated in GelMA Hydrogel. Int J Nanomedicine. 2024 Nov 8;19:11499-11516. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5926 mL | 17.9630 mL | 35.9260 mL | 89.8150 mL |
| 5 mM | 0.7185 mL | 3.5926 mL | 7.1852 mL | 17.9630 mL | |
| 10 mM | 0.3593 mL | 1.7963 mL | 3.5926 mL | 8.9815 mL | |
| 15 mM | 0.2395 mL | 1.1975 mL | 2.3951 mL | 5.9877 mL | |
| 20 mM | 0.1796 mL | 0.8981 mL | 1.7963 mL | 4.4907 mL | |
| 25 mM | 0.1437 mL | 0.7185 mL | 1.4370 mL | 3.5926 mL | |
| 30 mM | 0.1198 mL | 0.5988 mL | 1.1975 mL | 2.9938 mL | |
| 40 mM | 0.0898 mL | 0.4491 mL | 0.8981 mL | 2.2454 mL | |
| 50 mM | 0.0719 mL | 0.3593 mL | 0.7185 mL | 1.7963 mL | |
| 60 mM | 0.0599 mL | 0.2994 mL | 0.5988 mL | 1.4969 mL | |
| 80 mM | 0.0449 mL | 0.2245 mL | 0.4491 mL | 1.1227 mL | |
| 100 mM | 0.0359 mL | 0.1796 mL | 0.3593 mL | 0.8981 mL |
BNN6 Related Classifications
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