Butachlor
Based on 1 Customer Validation
Butachlor is defined as a commonly used acetanilide herbicide that exhibits varying levels of chronic toxicity to microalgae and acute toxicity to aquatic organisms. Butachlor butachlor adversely affected the normal reproductive success of zebrafish.
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- Pureza: 99.75%
- No. CAS: 23184-66-9
- Fòrmula: C17H26ClNO2
- Peso molecular:311.85
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Almacenamiento:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Traditional Chinese Medicine Active Compound Library
HY-L065
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Human Metabolite Library
HY-L123
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HY-L153
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Actividad biológica
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:zebrafish[1]
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Dosage:0, 25, 50 and 100 μg/L
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Administration:30 days
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Result:The mean fecundity rates were significantly decreased at 50 and 100 μg/L.
No significant changes were observed in condition factor and liver somatic index in both females and males, while GSI was significantly reduced in males at 50 and 100 μg/L.
At 100 μg/L, plasma testosterone and 17β-estradiol (E2) levels were significantly decreased in females, while plasma vitellogenin level was significantly increased in males.
Plasma thyroxine (T4) and triiodothyronine (T3) levels were significantly increased at 50 and 100 μg/L in males, and at 100 μg/L in females.
Chemical Information
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No. CAS 23184-66-9
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Appearance Liquid (Density: 1.07 g/cm3)
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Peso molecular 311.85
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Fòrmula C17H26ClNO2
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Color Colorless to light yellow
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SMILES
O=C(N(COCCCC)C1=C(CC)C=CC=C1CC)CCl
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (320.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Acetone : ≥ 100 mg/mL (320.67 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.02 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.02 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (537 KB)
- English - EN (537 KB)
- Français - FR (537 KB)
- Deutsch - DE (537 KB)
- Norwegian - NO (537 KB)
- Español - ES (537 KB)
- Swedish - SV (537 KB)
- Italian - IT (537 KB)
- Korean - KR (537 KB)
- Portuguese - PT (537 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Jie Liu , et al. Enhanced Dissipation of Xenobiotic Agrochemicals Harnessing Soil Microbiome in the Tillage-Reduced Rice-Dominated Agroecosystem. J Hazard Mater. 2020 May 25;398:122954. [Content Brief]
[2]. Chang J, et al. Effects of butachlor on reproduction and hormone levels in adult zebrafish (Danio rerio). Exp Toxicol Pathol. 2013 Jan;65(1-2):205-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / Acetone | 1 mM | 3.2067 mL | 16.0333 mL | 32.0667 mL | 80.1667 mL |
| 5 mM | 0.6413 mL | 3.2067 mL | 6.4133 mL | 16.0333 mL | |
| 10 mM | 0.3207 mL | 1.6033 mL | 3.2067 mL | 8.0167 mL | |
| 15 mM | 0.2138 mL | 1.0689 mL | 2.1378 mL | 5.3444 mL | |
| 20 mM | 0.1603 mL | 0.8017 mL | 1.6033 mL | 4.0083 mL | |
| 25 mM | 0.1283 mL | 0.6413 mL | 1.2827 mL | 3.2067 mL | |
| 30 mM | 0.1069 mL | 0.5344 mL | 1.0689 mL | 2.6722 mL | |
| 40 mM | 0.0802 mL | 0.4008 mL | 0.8017 mL | 2.0042 mL | |
| 50 mM | 0.0641 mL | 0.3207 mL | 0.6413 mL | 1.6033 mL | |
| 60 mM | 0.0534 mL | 0.2672 mL | 0.5344 mL | 1.3361 mL | |
| 80 mM | 0.0401 mL | 0.2004 mL | 0.4008 mL | 1.0021 mL | |
| 100 mM | 0.0321 mL | 0.1603 mL | 0.3207 mL | 0.8017 mL |
Butachlor Related Classifications
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