Cefotiam
Cefotiam (SCE-963) is a parenteral cephalosporin antibiotic. Cefotiam has broad-spectrum activity against Gram-positive and Gram-negative bacteria.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 61622-34-2
- Fòrmula: C18H23N9O4S3
- Peso molecular:525.63
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Ver todos los productos específicos de isoformas Antibiotic
More
Actividad biológica
|
β-lactam |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Oocyte | IC50 |
718 μM
Compound: Cefotiam
|
TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes
TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes
|
[PMID: 15618660] |
Cefotiam (SCE-963; 0-6.25μg/mL; 8 h) has antibacterial activity with a MIC value of 1.56 μg/mL for P. mirabilis IFO 3849[1].
Cefotiam (0-6.25μg/mL; 8 h) has highly active against both Staph. aureus (27 strains, MIC values of 0.5-1 μg/mL) and Staph. albus (8 strains, MICs 0.25-0.5 μg/mL). All 29 strains of haemolytic streptococci, 9 strains of pneumococci and 6 strains of Streptococcus viridans with the MIC values of in the range 0.06-4 μg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Female CF1/b mice with P. mirabilis xenograft[1]
-
Dosage:12.5, 25, 50, 100, 200, 400 and 800 mg/kg
-
Administration:Subcutaneous injection; twice a day, for 5 days
-
Result:Reduced or complete eradicated bacteria in the bladder walls and kidneys of mice sacrificed the day after treatment was terminated.
Chemical Information
-
No. CAS 61622-34-2
-
Peso molecular 525.63
-
Fòrmula C18H23N9O4S3
-
SMILES
O=C(C(N12)=C(CSC3=NN=NN3CCN(C)C)CS[C@]2([H])[C@H](NC(CC4=CSC(N)=N4)=O)C1=O)O
-
Synonyms
SCE-963; Cefotiam Dihydrochloride
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Iwahi T, et, al. Comparative activities of cefotiam and cefazolin against urinary tract infections with Proteus mirabilis in mice. Antimicrob Agents Chemother. 1980 Aug;18(2):257-63. [Content Brief]
[2]. Watt B, et, al. In-vitro activity of cefotiam against bacteria of clinical interest. J Antimicrob Chemother. 1982 Nov;10(5):391-5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cefotiam Related Classifications
HY-B0734 Related Classifications
Powered by Bioz