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Referencia número: HY-W110138

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Chloroxoquinoline

Chloroxoquinoline is an anticancer agent. Chloroxoquinoline damages the DNA templates of cancer cells, inducing DNA breaks and cell death, and inhibits cell invasion via down-regulating Rho/Rho kinase signaling pathway. Chloroxoquinoline enhances the radiation sensitivity of Lewis lung cancer cells and xenograft tumors in tumor-bearing mouse models but decreases efficacy after long term exposure in rat models by auto-induction effects on CYP1A and CYP3A. Chloroxoquinoline has a broad-spectrum anticancer activity, such as non-small-cell lung carcinoma (NSCLC), breast cancer and gastric cancer.

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No. CAS: 23833-97-8
Fòrmula: C₉H₆ClNO
Peso molecular:179.60

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Chloroxoquinoline Chemical Structure

No. CAS: 23833-97-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
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- Cellular Effect
Chemical Information
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Actividad biológica

Descripciòn

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Cellular Effect

Cell Line	Type	Value	Description	References
BGC-823	IC₅₀	>10 μM Compound: 11	Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay	[PMID: 30496987]
BGC-823	IC₅₀	>50 μM Compound: 1	Cytotoxicity against human BGC823 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay Cytotoxicity against human BGC823 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay	[PMID: 28757067]
BGC-823	IC₅₀	>50 μM Compound: 1	Cytotoxicity against human BGC823 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human BGC823 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 28942112]
DLD-1	IC₅₀	>10 μM Compound: 11	Cytotoxicity against human DLD1 cells after 48 hrs by MTT assay Cytotoxicity against human DLD1 cells after 48 hrs by MTT assay	[PMID: 30496987]
HCT-116	IC₅₀	>10 μM Compound: 11	Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 30496987]
HCT-116	IC₅₀	>50 μM Compound: 1	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 28942112]
HCT-8	IC₅₀	>50 μM Compound: 1	Cytotoxicity against human HCT8 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay Cytotoxicity against human HCT8 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay	[PMID: 28757067]
HCT-8	IC₅₀	>50 μM Compound: 1	Cytotoxicity against human HCT8 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human HCT8 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 28942112]
HeLa	IC₅₀	>50 μM Compound: 1	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay	[PMID: 28757067]
HeLa	IC₅₀	>50 μM Compound: 1	Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 28942112]
HEp-2	IC₅₀	>50 μM Compound: 1	Cytotoxicity against human Hep2 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay Cytotoxicity against human Hep2 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay	[PMID: 28757067]
HEp-2	IC₅₀	>50 μM Compound: 1	Cytotoxicity against human Hep2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human Hep2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 28942112]
HepG2	IC₅₀	>10 μM Compound: 11	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 30496987]
HepG2	IC₅₀	>50 μM Compound: 1	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay	[PMID: 28757067]
HepG2	IC₅₀	>50 μM Compound: 1	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 28942112]
MCF7	IC₅₀	>50 μM Compound: 1	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay	[PMID: 28757067]
MCF7	IC₅₀	>50 μM Compound: 1	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 28942112]
NCI-H1650	IC₅₀	>10 μM Compound: 11	Cytotoxicity against human NCI-H1650 cells after 48 hrs by MTT assay Cytotoxicity against human NCI-H1650 cells after 48 hrs by MTT assay	[PMID: 30496987]
PC-3	IC₅₀	>50 μM Compound: 1	Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay	[PMID: 28757067]
PC-3	IC₅₀	>50 μM Compound: 1	Cytotoxicity against human PC3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human PC3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 28942112]
RKO	IC₅₀	>10 μM Compound: 11	Cytotoxicity against human RKO cells after 48 hrs by MTT assay Cytotoxicity against human RKO cells after 48 hrs by MTT assay	[PMID: 30496987]
RKO	IC₅₀	>50 μM Compound: 1	Cytotoxicity against human RKO cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human RKO cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 28942112]
SK-OV-3	IC₅₀	>10 μM Compound: 11	Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay	[PMID: 30496987]

Chemical Information

No. CAS 23833-97-8
Peso molecular 179.60
Fòrmula C₉H₆ClNO
SMILES

O=C1C=CNC2=C1C=CC(Cl)=C2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Li X, et al. Auto-Induction Effect of Chloroxoquinoline on the Cytochrome P450 Enzymes of Rats Associated with CYP 3A and 1A. PLoS One. 2015 Sep 23;10(9):e0138875. [Content Brief]

[2]. Liu J, et al. [Chloroxoquinoline inhibits invasion in breast cancer via down-regulating Rho/Rho kinase signaling pathway]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2019 Dec 25;48(6):631-637. Chinese. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Chloroxoquinoline

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