CKD-731
CKD-731 is a Fumagillin (HY-B0751) analogue. CKD-731 inhibits the proliferation of calf pulmonary artery endothelial cells (CPAE), lymphoma EL-4 cells and murine leukemia P388D1 cells. CKD-731 exerts the effect of inhibiting MetAP-2 activity and blocking angiogenesis. CKD-731 can be used for the research of anti-angiogenesis-related cancer.
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- No. CAS: 251111-15-6
- Fòrmula: C28H38O8
- Peso molecular:502.60
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CPAE | IC50 |
0.00003 ng/mL
Compound: 3d
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Tested in vitro for its ability to inhibit cell proliferation of calf pulmonary artery endothelial cells measured calorimetrically by SRB method
Tested in vitro for its ability to inhibit cell proliferation of calf pulmonary artery endothelial cells measured calorimetrically by SRB method
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[PMID: 10636239] |
| CPAE | IC50 |
0.03 μg/mL
Compound: S10
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Cytotoxic activity against cow CPAE cells by MTT assay
Cytotoxic activity against cow CPAE cells by MTT assay
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[PMID: 31009908] |
| EL4 | IC50 |
0.00015 ng/mL
Compound: 3d
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Tested in vitro for its ability to inhibit cell proliferation of lymphoma EL-4 cells measured calorimetrically by MTT method
Tested in vitro for its ability to inhibit cell proliferation of lymphoma EL-4 cells measured calorimetrically by MTT method
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[PMID: 10636239] |
| EL4 | IC50 |
0.15 μg/mL
Compound: S10
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Antitumor activity against mouse EL4 cells by MTT assay
Antitumor activity against mouse EL4 cells by MTT assay
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[PMID: 31009908] |
| P388 | IC50 |
>1 ng/mL
Compound: 3d
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Tested in vitro for its ability to inhibit cell proliferation of murine leukemia P388D1 cells measured calorimetrically by MTT method
Tested in vitro for its ability to inhibit cell proliferation of murine leukemia P388D1 cells measured calorimetrically by MTT method
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[PMID: 10636239] |
Chemical Information
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No. CAS 251111-15-6
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Peso molecular 502.60
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Fòrmula C28H38O8
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SMILES
O=C(O[C@H](CC1)[C@@H](OC)[C@H]([C@@]2(C)O[C@@H]2C/C=C(C)\C)[C@]31CO3)/C=C/C4=CC(OC)=C(OC)C(OC)=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CKD-731 Related Classifications
HY-103653 Related Classifications
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