DAP-81
DAP-81 is an inhibitory agent targeting Polo-like kinases (Plks), a class of evolutionarily conserved serine/threonine kinases. DAP-81 dose-dependently increases the number of monopolar spindles in treated cells. High-resolution live-cell microscopy revealed that Plk activity is required for the assembly and maintenance of bipolar mitotic spindles. Plk inhibition destabilizes centromeric microtubules while stabilizing other spindle microtubules, leading to the formation of monopolar spindles. Further testing of compounds based on "privileged scaffolds" such as the DAP scaffold may lead to the discovery of new cell division probes and anti-microtubule agents.
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- No. CAS: 794466-17-4
- Fòrmula: C25H20N6O4
- Peso molecular:468.46
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BSC-1 | EC50 |
5 μM
Compound: 1, DAP-81
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Antimitotic activity against african green monkey BSC1 cells assessed as induction of monopolar spindles by immunofluorescence microscopy
Antimitotic activity against african green monkey BSC1 cells assessed as induction of monopolar spindles by immunofluorescence microscopy
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[PMID: 17028580] |
Chemical Information
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No. CAS 794466-17-4
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Peso molecular 468.46
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Fòrmula C25H20N6O4
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SMILES
CC(NC1=CC=C(C=C1)NC2=NC=C(C(NC3=CC=CC=C3C(C4=CC=CC=C4)=O)=N2)[N+]([O-])=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DAP-81 Related Classifications
HY-121634 Related Classifications
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