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Referencia número: HY-131923

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DAPM

DAPM is a Notch pathway inhibitor with anticancer activity and antiproliferative effects. DAPM effectively inhibits tubular adenoma development by inhibiting cell proliferation and inducing the expression of Krüppel-like factor 4 (KLF4) and p21 in human colon cancer cells.

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No. CAS: 208255-51-0
Fòrmula: C₂₀H₂₀F₂N₂O₄
Peso molecular:390.38

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

DAPM Chemical Structure

No. CAS: 208255-51-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
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Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	12 μM Compound: DAPM	Antiproliferative activity against human HCT116 cells after 72 hrs by SYBR green dye based fluorescence assay Antiproliferative activity against human HCT116 cells after 72 hrs by SYBR green dye based fluorescence assay	[PMID: 30201292]

Chemical Information

No. CAS 208255-51-0
Peso molecular 390.38
Fòrmula C₂₀H₂₀F₂N₂O₄
Sequence

N-[N-3,5-Difluorophenacetyl]-L-alanyl-S-phenylglycine methyl ester
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Miyamoto S, et al. Suppression of colon carcinogenesis by targeting Notch signaling. Carcinogenesis. 2013 Oct;34(10):2415-23. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Actividad biológica
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Chemical Information
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DAPM

High-Throughput Bioactive Compound Library

Actividad biológica

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DAPM Related Classifications

HY-131923 Related Classifications