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Referencia número: HY-187697

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DB1255

DB1255 is an ERG inhibitor that binds to the minor groove of DNA, with K_D values of 26 nM and 86 nM for the ATGA and AATT sequences, respectively. DB1255 targets and binds to specific DNA minor grooves (single GC/AT-rich sequences), forming a hydrogen bond network with G bases and AT pairs via its thiophene group and amidino group, respectively, thereby blocking the binding of transcription factors. DB1255 can be used in the research of leukemia and prostate cancer.

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No. CAS: 915978-94-8
Fòrmula: C₂₂H₁₈N₄S₂
Peso molecular:402.53

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

DB1255 Chemical Structure

No. CAS: 915978-94-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
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Actividad biológica

Descripciòn

In Vitro

DB1255 (0.25-1.5 μM; 15 min) strongly and specifically binds to the minor groove of DNA and protects DNA fragments with a 265 bp 3'-end label from DNase I digestion^[1].
DB1255 (at DNA molar ratios of 1:1 and 2:1) significantly increases the Tm and stabilizes the DNA double strand in a system containing 3 μM DNA hairpin oligonucleotide duplex^[1].
At a molar ratio of DB1255 to DNA ranging from 0.25 to 2.0 (monitored in real time), DB1255 induces a strong positive circular dichroism signal and exhibits a 1:1 monomer binding mode in a DNA hairpin duplex (3 μM) system^[1].
DB1255 (0.001-0.3 μM) exerts high-affinity monomer binding in a surface plasmon resonance biosensor system immobilized with 5'-biotinylated DNA, with K_D values of 26 nM and 86 nM for sequences containing ATGA and AATT, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 915978-94-8
Peso molecular 402.53
Fòrmula C₂₂H₁₈N₄S₂
SMILES

N=C(N)C=1C=CC(=CC1)C=2SC(=CC2)C=3SC(=CC3)C=4C=CC(=CC4)C(=N)N
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Munde M, et al. The unusual monomer recognition of guanine-containing mixed sequence DNA by a dithiophene heterocyclic diamidine. Biochemistry. 2014 Feb 25;53(7):1218-27.

Calculators

Calculadora de molaridad

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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