DC-BPi-11
DC-BPi-11 is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC50 value of 698 nM. DC-BPi-11 shows remarkable inhibition against leukemia cell proliferation.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2758411-61-7
- Fòrmula: C20H23N5O2S
- Peso molecular:397.49
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Ver todos los productos específicos de isoformas SWI/SNF Complex
More
Actividad biológica
698 nM (BPTF)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MV4-11 | IC50 |
0.89 μM
Compound: DC-BPi-11
|
Antiproliferative activity against human MC4-11 cells assessed as reduction in cell viability after 5 days by Celltiter-Glo assay
Antiproliferative activity against human MC4-11 cells assessed as reduction in cell viability after 5 days by Celltiter-Glo assay
|
[PMID: 34375106] |
DC-BPi-11 (0.1 nM-1 μM; 24 h) inhibits BPTF in human leukemia MV-4-11 cells with an EC50 value of 120 nM[1].
DC-BPi-11 (0.01 μM-100 μM; 24 h) significantly inhibits the proliferation of human leukemia MV-4-11 cells (IC50=0.89 μM), and (2.5-20 μM; 24 h) decreases downstream oncogene expression[1].
DC-BPi-11 (0.6-50 μM; 24 h) dose-dependently decreases c-Myc protein level[1].
DC-BPi-11 is safety and shows minimal effects on normal cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Human leukemia MV-4-11 cells
-
Concentration:0.6 μM, 1.8 μM, 5.6 μM, 16.6 μM, and 50 μM
-
Incubation Time:24 hours
-
Result:Resulted depletion of c-Myc in a dose-dependent manner.
-
Cell Line:Human leukemia MV-4-11 cells
-
Concentration:5 μM, 10 μM, 20 μM
-
Incubation Time:24 hours
-
Result:Induced cell apoptosis by arresting cell cycle at G1 phase.
Chemical Information
-
No. CAS 2758411-61-7
-
Peso molecular 397.49
-
Fòrmula C20H23N5O2S
-
SMILES
CN(C)CCCN1C=CC2=C1C=CC(C3=NC(S(C)(=O)=O)=NC4=C3C=CN4)=C2
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DC-BPi-11 Related Classifications
HY-141703 Related Classifications
Powered by Bioz