DGDG
Based on 1 Customer Validation
DGDG, a chloroplast lipid, is a bilayer-forming lipid. DGDG is important for photosynthesis, and can be used for drug delivery.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 63142-69-8
- Fòrmula: C51H84O15
- Peso molecular:937.20
-
Almacenamiento:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Vero | CC50 |
>100 μg/mL
Compound: 1
|
Cytotoxicity against african green monkey Vero cells after 72 hrs by resazurin dye-based fluorimetric analysis
Cytotoxicity against african green monkey Vero cells after 72 hrs by resazurin dye-based fluorimetric analysis
|
[PMID: 22348826] |
Apart from facilitating the photosynthesis light reaction in the thylakoid membrane, DGDG is important for maintaining chloroplast morphology and for plant survival under abiotic stresses such as phosphate starvation and freezing. During phosphate limitation, the amounts of DGDG increase in the plastids of plants, and DGDG is exported to extraplastidial membranes to replace phospholipids[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 63142-69-8
-
Appearance Oil
-
Peso molecular 937.20
-
Fòrmula C51H84O15
-
Color Brown to black
-
SMILES
OC[C@H]([C@@H]([C@@H]([C@H]1O)O)O)O[C@@H]1OC[C@H]2O[C@H]([C@@H]([C@H]([C@H]2O)O)O)OC[C@H](OC(CCCCCCC/C=C\C/C=C\C/C=C\CC)=O)COC(CCCCCCC/C=C\C/C=C\C/C=C\CC)=O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (106.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (2.67 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (2.67 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
-
Ficha de datos (267 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0670 mL | 5.3350 mL | 10.6701 mL | 26.6752 mL |
| 5 mM | 0.2134 mL | 1.0670 mL | 2.1340 mL | 5.3350 mL | |
| 10 mM | 0.1067 mL | 0.5335 mL | 1.0670 mL | 2.6675 mL | |
| 15 mM | 0.0711 mL | 0.3557 mL | 0.7113 mL | 1.7783 mL | |
| 20 mM | 0.0534 mL | 0.2668 mL | 0.5335 mL | 1.3338 mL | |
| 25 mM | 0.0427 mL | 0.2134 mL | 0.4268 mL | 1.0670 mL | |
| 30 mM | 0.0356 mL | 0.1778 mL | 0.3557 mL | 0.8892 mL | |
| 40 mM | 0.0267 mL | 0.1334 mL | 0.2668 mL | 0.6669 mL | |
| 50 mM | 0.0213 mL | 0.1067 mL | 0.2134 mL | 0.5335 mL | |
| 60 mM | 0.0178 mL | 0.0889 mL | 0.1778 mL | 0.4446 mL | |
| 80 mM | 0.0133 mL | 0.0667 mL | 0.1334 mL | 0.3334 mL | |
| 100 mM | 0.0107 mL | 0.0534 mL | 0.1067 mL | 0.2668 mL |
Powered by Bioz