DJ101
Based on 1 Customer Validation
DJ101 is a potent and metabolically stable tubulin inhibitor. DJ101 targets the colchicine binding site and overcomes taxane resistance. DJ101 also inhibits melanoma tumor growth and lung metastasis. DJ101 can be used for prostate cancer research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.36%
- No. CAS: 1803242-21-8
- Fòrmula: C23H20N4O3
- Peso molecular:400.43
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
3 nM
Compound: 41
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Cytotoxicity against human A375 cells after 48 hrs by MTS assay
Cytotoxicity against human A375 cells after 48 hrs by MTS assay
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[PMID: 26396686] |
| DU-145 | IC50 |
14 nM
Compound: 41
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Cytotoxicity against human DU145 cells after 48 hrs by MTS assay
Cytotoxicity against human DU145 cells after 48 hrs by MTS assay
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[PMID: 26396686] |
| DU-145 | IC50 |
17 nM
Compound: 41
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Cytotoxicity against human paclitaxel-resistant DU145 cells after 48 hrs by MTS assay
Cytotoxicity against human paclitaxel-resistant DU145 cells after 48 hrs by MTS assay
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[PMID: 26396686] |
| M14 | IC50 |
14 nM
Compound: 41
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Cytotoxicity against human M14 cells after 48 hrs by MTS assay
Cytotoxicity against human M14 cells after 48 hrs by MTS assay
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[PMID: 26396686] |
| PC-3 | IC50 |
12 nM
Compound: 41
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Cytotoxicity against human paclitaxel-resistant PC3 cells after 48 hrs by MTS assay
Cytotoxicity against human paclitaxel-resistant PC3 cells after 48 hrs by MTS assay
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[PMID: 26396686] |
| PC-3 | IC50 |
7 nM
Compound: 41
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Cytotoxicity against human PC3 cells after 48 hrs by MTS assay
Cytotoxicity against human PC3 cells after 48 hrs by MTS assay
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[PMID: 26396686] |
Chemical Information
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No. CAS 1803242-21-8
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Appearance Solid
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Peso molecular 400.43
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Fòrmula C23H20N4O3
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Color Light yellow to yellow
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SMILES
COC1=C(OC)C(OC)=CC(C2=NC=CC3=C2N=C(C4=CC=CC5=C4C=CN5)N3)=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (249.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (6.24 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4973 mL | 12.4866 mL | 24.9732 mL | 62.4329 mL |
| 5 mM | 0.4995 mL | 2.4973 mL | 4.9946 mL | 12.4866 mL | |
| 10 mM | 0.2497 mL | 1.2487 mL | 2.4973 mL | 6.2433 mL | |
| 15 mM | 0.1665 mL | 0.8324 mL | 1.6649 mL | 4.1622 mL | |
| 20 mM | 0.1249 mL | 0.6243 mL | 1.2487 mL | 3.1216 mL | |
| 25 mM | 0.0999 mL | 0.4995 mL | 0.9989 mL | 2.4973 mL | |
| 30 mM | 0.0832 mL | 0.4162 mL | 0.8324 mL | 2.0811 mL | |
| 40 mM | 0.0624 mL | 0.3122 mL | 0.6243 mL | 1.5608 mL | |
| 50 mM | 0.0499 mL | 0.2497 mL | 0.4995 mL | 1.2487 mL | |
| 60 mM | 0.0416 mL | 0.2081 mL | 0.4162 mL | 1.0405 mL | |
| 80 mM | 0.0312 mL | 0.1561 mL | 0.3122 mL | 0.7804 mL | |
| 100 mM | 0.0250 mL | 0.1249 mL | 0.2497 mL | 0.6243 mL |
DJ101 Related Classifications
HY-121524 Related Classifications
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