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Referencia número: HY-161731

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DS08701581

DS08701581 is an inhibitor of FER tyrosine kinase with IC₅₀. DS08701581 has anti-tumor activity and oral activity.

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No. CAS: 3074776-78-3
Fòrmula: C₂₆H₃₂N₈O₂
Peso molecular:488.58

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

DS08701581 Chemical Structure

No. CAS: 3074776-78-3

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One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Protocolo (1)
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

DS08701581 is an inhibitor of FER tyrosine kinase with IC₅₀. DS08701581 has anti-tumor activity and oral activity^[1].

Ver todos los productos específicos de isoformas EGFR :

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	GI₅₀	0.67 nM Compound: 17c; DS08701581	Inhibition of cell viability in mouse BaF3 cells expressing FER incubated for 3 days by Cell Titer Glo assay Inhibition of cell viability in mouse BaF3 cells expressing FER incubated for 3 days by Cell Titer Glo assay	[PMID: 39015278]
BaF3	GI₅₀	1000 nM Compound: 17c; DS08701581	Inhibition of cell viability in mouse BaF3 cells incubated for 3 days by Cell Titer Glo assay Inhibition of cell viability in mouse BaF3 cells incubated for 3 days by Cell Titer Glo assay	[PMID: 39015278]

Chemical Information

No. CAS 3074776-78-3
Peso molecular 488.58
Fòrmula C₂₆H₃₂N₈O₂
SMILES

O=C1NN=CC2=C(C#N)C(N[C@H]3[C@@H](N)CCCC3)=NC(NC4=CC=CC(N5C[C@H](C)O[C@H](C)C5)=C4)=C21
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocolo

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Toru Taniguchi, et al. Optimization of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors, Leading to the Potent DS08701581. ACS Med. Chem. Lett. 2024

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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