DS37571084
DS37571084 is an orally active and potent antagonist of the parathyroid hormone type 1 receptor (PTHR1), with an IC50 value of 0.17 μM. DS37571084 can be used for the study of hyperparathyroidism.
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- No. CAS: 2460353-87-9
- Fòrmula: C28H30Cl2N4O2
- Peso molecular:525.47
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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PTH1R 0.17 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| CHO-K1 | IC50 |
0.17 μM
Compound: 12; DS37571084
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Antagonist activity at PTHR1 (unknown origin) expressed in CHOK1 cells co-expressing Gs/Gq assessed as reduction in human PTH (1 to 34 residues)-induced cAMP level incubated for 30 mins
Antagonist activity at PTHR1 (unknown origin) expressed in CHOK1 cells co-expressing Gs/Gq assessed as reduction in human PTH (1 to 34 residues)-induced cAMP level incubated for 30 mins
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[PMID: 32345459] |
Chemical Information
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No. CAS 2460353-87-9
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Peso molecular 525.47
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Fòrmula C28H30Cl2N4O2
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SMILES
O=C1N(C2=CC=C(NCCNC3CCOCC3)C=C2)C4=CC(Cl)=CC=C4C5=CC(Cl)=CN=C5C1(C)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DS37571084 Related Classifications
HY-131206 Related Classifications
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