DS39201083
DS39201083, a Conolidine derivative, is a potent and orally active analgesic agent. DS39201083 shows no agonist activity at the mu opioid receptor. DS39201083 can be used for the study of neurological diseases.
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- No. CAS: 2361560-81-6
- Fòrmula: C16H18N2O
- Peso molecular:254.33
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
DS39201083 exhibits an IC50 of 71 μM in the mu-opioid receptor (MOR) binding assay; in the functional MOR cAMP assay, it demonstrates an EC50 >100 μM and an Emax of 12%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
DS39201083 shows excellent dose-dependent activity in the acetic acid-induced writhing test in Slc:ddY mice (ED50=7.8 mg/kg; 23%, 52%, and 94% inhibition at 3, 10, and 30 mg/kg, respectively)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:3.5% formalin (20 µL) was injected into the hind paw pad of Slc:ddY mice[1].
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Dosage:30 mg/kg
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Administration:Oral gavage, once, before 3.5% formalin (20 µL) was injected into the hind paw pad.
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Result:Showed a 92% inhibition rate of initial phase pain.
Chemical Information
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No. CAS 2361560-81-6
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Peso molecular 254.33
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Fòrmula C16H18N2O
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SMILES
O=C1C2=C(CN3CCC1(CC3)C)C4=C(C=CC=C4)N2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DS39201083 Related Classifications
HY-128624 Related Classifications
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