Dynarrestin
Based on 5 publication(s) in Google Scholar
Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin rapidly and reversibly inhibits dynein 1-driven microtubule gliding in vitro plus a range of dynein 1- and 2-dependent processes in cells without affecting ATP hydrolysis and interfering with ciliogenesis. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells.
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- Pureza: 98.18%
- No. CAS: 2222768-84-3
- Fòrmula: C22H23F2N3O2S
- Peso molecular:431.50
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Almacenamiento:
4°C, protect from light
* The compound is unstable in solutions, freshly prepared is recommended.
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Dynarrestin
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Actividad biológica
Chemical Information
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No. CAS 2222768-84-3
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Appearance Solid
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Peso molecular 431.50
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Fòrmula C22H23F2N3O2S
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Color Light brown to brown
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SMILES
O=C(C1=C(C2=CC=C(N(CC)CC)C=C2)N=C(NC3=CC=C(F)C=C3F)S1)OCC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* The compound is unstable in solutions, freshly prepared is recommended.
Publications (5)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Pericentrosomal Redistribution of the Endoplasmic Reticulum Ensures Organelle Symmetric Inheritance and Mitotic Progression. [Abstract]2026 Jun 22:e76193. PMID: 42325213 -
Free Radic Biol Med
Targeted nuclear degranulation of neutrophils in the shock stage of severe burns drives rapid neutrophil extracellular trap release during infection to mediate acute lung injury. [Abstract]2025 Dec 9:244:107-119. PMID: 41371002 -
Curr Biol
The chirality of the mitotic spindle provides a mechanical response to forces and depends on microtubule motors and augmin. [Abstract]2022 Jun 6;32(11):2480-2493.e6. PMID: 35537456 -
J Cell Biol
Septin-coated microtubules promote maturation of multivesicular bodies by inhibiting their motility. [Abstract]2024 Aug 5;223(8):e202308049. PMID: 38668767 -
Solvente y solubilidad
DMSO : 83.33 mg/mL (193.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Pureza y Documentación
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Ficha de datos (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3175 mL | 11.5875 mL | 23.1750 mL | 57.9374 mL |
| 5 mM | 0.4635 mL | 2.3175 mL | 4.6350 mL | 11.5875 mL | |
| 10 mM | 0.2317 mL | 1.1587 mL | 2.3175 mL | 5.7937 mL | |
| 15 mM | 0.1545 mL | 0.7725 mL | 1.5450 mL | 3.8625 mL | |
| 20 mM | 0.1159 mL | 0.5794 mL | 1.1587 mL | 2.8969 mL | |
| 25 mM | 0.0927 mL | 0.4635 mL | 0.9270 mL | 2.3175 mL | |
| 30 mM | 0.0772 mL | 0.3862 mL | 0.7725 mL | 1.9312 mL | |
| 40 mM | 0.0579 mL | 0.2897 mL | 0.5794 mL | 1.4484 mL | |
| 50 mM | 0.0463 mL | 0.2317 mL | 0.4635 mL | 1.1587 mL | |
| 60 mM | 0.0386 mL | 0.1931 mL | 0.3862 mL | 0.9656 mL | |
| 80 mM | 0.0290 mL | 0.1448 mL | 0.2897 mL | 0.7242 mL | |
| 100 mM | 0.0232 mL | 0.1159 mL | 0.2317 mL | 0.5794 mL |
Dynarrestin Related Classifications
HY-121802 Related Classifications
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