EO 1428
Based on 1 Customer Validation
EO 1428 is a highly specific inhibitor of p38 of the aminobenzophenone class. EO 1428 (1 μM ) markedly attenuates LPS-induced tumor necrosis factor α-converting enzyme (TACE) activity up-regulation.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.65%
- No. CAS: 321351-00-2
- Fòrmula: C20H16BrClN2O
- Peso molecular:415.71
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PBMC | IC50 |
14 nM
Compound: 14
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Anti-inflammatory activity in human PBMC cells assessed as inhibition of LPS-induced IL-beta production
Anti-inflammatory activity in human PBMC cells assessed as inhibition of LPS-induced IL-beta production
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[PMID: 30542530] |
| PBMC | IC50 |
4 nM
Compound: 14
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Anti-inflammatory activity in human PBMC cells assessed as inhibition of LPS-induced TNF-alpha production
Anti-inflammatory activity in human PBMC cells assessed as inhibition of LPS-induced TNF-alpha production
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[PMID: 30542530] |
Chemical Information
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No. CAS 321351-00-2
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Appearance Solid
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Peso molecular 415.71
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Fòrmula C20H16BrClN2O
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Color White to yellow
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SMILES
O=C(C1=CC=C(NC2=CC=C(Br)C=C2N)C=C1Cl)C3=CC=CC=C3C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (240.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4055 mL | 12.0276 mL | 24.0552 mL | 60.1381 mL |
| 5 mM | 0.4811 mL | 2.4055 mL | 4.8110 mL | 12.0276 mL | |
| 10 mM | 0.2406 mL | 1.2028 mL | 2.4055 mL | 6.0138 mL | |
| 15 mM | 0.1604 mL | 0.8018 mL | 1.6037 mL | 4.0092 mL | |
| 20 mM | 0.1203 mL | 0.6014 mL | 1.2028 mL | 3.0069 mL | |
| 25 mM | 0.0962 mL | 0.4811 mL | 0.9622 mL | 2.4055 mL | |
| 30 mM | 0.0802 mL | 0.4009 mL | 0.8018 mL | 2.0046 mL | |
| 40 mM | 0.0601 mL | 0.3007 mL | 0.6014 mL | 1.5035 mL | |
| 50 mM | 0.0481 mL | 0.2406 mL | 0.4811 mL | 1.2028 mL | |
| 60 mM | 0.0401 mL | 0.2005 mL | 0.4009 mL | 1.0023 mL | |
| 80 mM | 0.0301 mL | 0.1503 mL | 0.3007 mL | 0.7517 mL | |
| 100 mM | 0.0241 mL | 0.1203 mL | 0.2406 mL | 0.6014 mL |
EO 1428 Related Classifications
HY-108647 Related Classifications
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