Etoxadrol
Etoxadrol (CL-1848C) is a potent, high-affinity N-methyl-D-aspartic acid (NMDA) antagonist. Etoxadrol is used in the anaesthetic and anaesthesia research community to suppress or relieve pain.
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- No. CAS: 28189-85-7
- Fòrmula: C16H23NO2
- Peso molecular:261.36
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
NMDA[1]
Etoxadrol (0-20 mg/kg; i.v.; once) decreases brain monoamine concentrations after 4 h injection[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Carworth-Farm (Upjohn) male mice weighing 18 to 20 gm[2]
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Dosage:100.0 mg/kg
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Administration:Subcutaneous injection, 30 min
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Result:Produced marked stimulation and ataxia.
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Animal Model:Male CFE rats weighing 110-175 g (average 130 g)[3]
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Dosage:5, 10, and 20 mg/kg
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Administration:Intravenous injection, once
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Result:Significantly lowered brain serotonin, DA (dopamine), and NE (norepinephrine) concentrations at 4 h.
Chemical Information
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No. CAS 28189-85-7
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Peso molecular 261.36
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Fòrmula C16H23NO2
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SMILES
CC[C@@]1(C2=CC=CC=C2)O[C@]([C@]3([H])CCCCN3)([H])CO1
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Synonyms
NSC 288020; CL-1848C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. A Thurkauf, et al. Synthesis, absolute configuration, and molecular modeling study of etoxadrol, a potent phencyclidine-like agonist. J Med Chem. 1988 Dec;31(12):2257-63. [Content Brief]
[2]. A H Tang, et al. Analgetic activities of etoxadrol in the rhesus monkey and in mice. Anesth Analg. 1973 Jul-Aug;52(4):577-83. [Content Brief]
[3]. Y F Sung, et al. Effects of intravenous anesthetics on brain monoamines in the rat. Anesthesiology. 1973 Nov;39(5):478-87. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Etoxadrol Related Classifications
HY-107040 Related Classifications
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