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Referencia número: HY-119060

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FP0429

FP0429 is a full mGlu4 agonist and partial mGlu8 agonist with EC₅₀ values of 48.3 μM and 56.2 μM, respectively.

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No. CAS: 870860-41-6
Fòrmula: C₁₀H₁₂N₂O₇
Peso molecular:272.21

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

FP0429 Chemical Structure

No. CAS: 870860-41-6

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Actividad biológica
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Chemical Information
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Actividad biológica

Descripciòn

FP0429 is a full mGlu4 agonist and partial mGlu8 agonist with EC₅₀ values of 48.3 μM and 56.2 μM, respectively^[1].

Ver todos los productos específicos de isoformas mGluR :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	>5000 μM Compound: 8a06, FP0429	Activity at rat mGluR2 receptor measured as intracellular calcium concentration in HEK293 cells Activity at rat mGluR2 receptor measured as intracellular calcium concentration in HEK293 cells	[PMID: 16828551]
HEK293	EC₅₀	>5000 μM Compound: 8a06, FP0429	Activity at rat mGluR5 receptor measured as intracellular calcium concentration in HEK293 cells Activity at rat mGluR5 receptor measured as intracellular calcium concentration in HEK293 cells	[PMID: 16828551]
HEK293	EC₅₀	378 μM Compound: 8a06, FP0429	Activity at rat mGluR6 receptor measured as intracellular calcium concentration in HEK293 cells Activity at rat mGluR6 receptor measured as intracellular calcium concentration in HEK293 cells	[PMID: 16828551]
HEK293	EC₅₀	48.3 μM Compound: 8a06, FP0429	Activity at rat mGluR4 receptor measured as intracellular calcium concentration in HEK293 cells Activity at rat mGluR4 receptor measured as intracellular calcium concentration in HEK293 cells	[PMID: 16828551]
HEK293	EC₅₀	56.2 μM Compound: 8a06, FP0429	Activity at rat mGluR8 receptor measured as intracellular calcium concentration in HEK293 cells Activity at rat mGluR8 receptor measured as intracellular calcium concentration in HEK293 cells	[PMID: 16828551]
HEK293	EC₅₀	>5000 μM Compound: 8a06, FP0429	Activity at rat mGluR1 receptor measured as intracellular calcium concentration in HEK293 cells Activity at rat mGluR1 receptor measured as intracellular calcium concentration in HEK293 cells	[PMID: 16828551]

Chemical Information

No. CAS 870860-41-6
Peso molecular 272.21
Fòrmula C₁₀H₁₂N₂O₇
SMILES

O=C(O)[C@H]1N(C[C@@](N)(C1)C(O)=O)C(/C=C/C(O)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Schann S, et al. Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): identification of a new group III metabotropic glutamate receptor selective agonist. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4856-60. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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FP0429

Ver todos los productos específicos de isoformas mGluR

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

FP0429 Related Classifications

HY-119060 Related Classifications