G907
Based on 1 publication(s) in Google Scholar
G907 is a selective antagonist of ATP-binding cassette (ABC) transporter MsbA with anti-microbial activity. G907 inhibits E. coli MsbA with an IC50 value of 18 nM. G907 traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket.
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- Pureza: 98.06%
- No. CAS: 2244035-16-1
- Fòrmula: C26H24ClNO3
- Peso molecular:433.93
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) G907
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Actividad biológica
IC50: 18 nM (ABC transporter)[1]
G907 (0.1 nM-100 μM) inhibits the activity of purified E. coli MsbA in amphipols with an IC50 value of 18 nM[1]. G907 shows allosteric inhibition to MsbA[1]. G907 (100 nM) completely inhibits transport activity of biotin-PE in MsbA-WT-containing proteoliposomes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2244035-16-1
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Appearance Solid
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Peso molecular 433.93
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Fòrmula C26H24ClNO3
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Color White to off-white
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SMILES
O=C(O)/C=C/C1=C(C2CC2)C3=CC(OC(C4=C(C5CC5)C=CC=C4Cl)C)=CC=C3N=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Commun Biol
2024 Jan 5;7(1):43. PMID: 38182790
Solvente y solubilidad
DMSO : 83.33 mg/mL (192.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3045 mL | 11.5226 mL | 23.0452 mL | 57.6130 mL |
| 5 mM | 0.4609 mL | 2.3045 mL | 4.6090 mL | 11.5226 mL | |
| 10 mM | 0.2305 mL | 1.1523 mL | 2.3045 mL | 5.7613 mL | |
| 15 mM | 0.1536 mL | 0.7682 mL | 1.5363 mL | 3.8409 mL | |
| 20 mM | 0.1152 mL | 0.5761 mL | 1.1523 mL | 2.8806 mL | |
| 25 mM | 0.0922 mL | 0.4609 mL | 0.9218 mL | 2.3045 mL | |
| 30 mM | 0.0768 mL | 0.3841 mL | 0.7682 mL | 1.9204 mL | |
| 40 mM | 0.0576 mL | 0.2881 mL | 0.5761 mL | 1.4403 mL | |
| 50 mM | 0.0461 mL | 0.2305 mL | 0.4609 mL | 1.1523 mL | |
| 60 mM | 0.0384 mL | 0.1920 mL | 0.3841 mL | 0.9602 mL | |
| 80 mM | 0.0288 mL | 0.1440 mL | 0.2881 mL | 0.7202 mL | |
| 100 mM | 0.0230 mL | 0.1152 mL | 0.2305 mL | 0.5761 mL |
G907 Related Classifications
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