Gastrazole
Gastrazole (JB95008) is potent and selective CCK2/gastrin receptor antagonist. Gastrazole can decrease the level of gastric acid. Gastrazole inhibits the Gastrin-stimulated growth of pancreatic cancer.
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- No. CAS: 862583-15-1
- Fòrmula: C34H32FN5Na2O7
- Peso molecular:687.63
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
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CCKBR |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats with a gastric fistula[2]
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Dosage:0.15, 0.3, 3 mg/kg
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Administration:Intravenous administration
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Result:Dose-dependently inhibited Pentagastrin-stimulation acid secretion by maximally 73%.
Chemical Information
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No. CAS 862583-15-1
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Peso molecular 687.63
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Fòrmula C34H32FN5Na2O7
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SMILES
O=C(C(C=C(NC=N1)C1=C2)=C2C(NCC3CCCCCC3)=O)N[C@H](C(NC4=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C4)=O)CC(C=CC=C5)=C5F
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Synonyms
JB95008
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Chau I, et, al. Gastrazole (JB95008), a novel CCK2/gastrin receptor antagonist, in the treatment of advanced pancreatic cancer: results from two randomised controlled trials. Br J Cancer. 2006 Apr 24;94(8):1107-15. [Content Brief]
[2]. Rudholm T, et, al. Release of regulatory gut peptides somatostatin, neurotensin and vasoactive intestinal peptide by acid and hyperosmolal solutions in the intestine in conscious rats. Regul Pept. 2009 Jan 8;152(1-3):8-12. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Gastrazole Related Classifications
HY-19445 Related Classifications
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