Copy Link Print Information

H-151

158 Cited Publications
Revisión del cliente

Based on 158 publication(s) in Google Scholar

H-151 is a potent, selective and covalent antagonist of STING that has noteworthy inhibitory activity both in cells and in vivo. H-151 reduces TBK1 phosphorylation and suppresses STING palmitoylation. H-151 can be used for the research of autoinflammatory disease.

Para uso exclusivo en investigación. No vendemos a pacientes.

  • Pureza: 99.78%
  • No. CAS: 941987-60-6
  • Fòrmula: C17H17N3O
  • Peso molecular:279.34
  • Almacenamiento:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • H-151 Chemical Structure
    H-151 Chemical Structure
  • Experimental Validation Results for H-151
  • Experimental Validation Results for H-151
  • Experimental Validation Results for H-151
  • Experimental Validation Results for H-151
  • Experimental Validation Results for H-151
  • Experimental Validation Results for H-151
No. CAS: 941987-60-6
Tamaño
Precio
Stock
Cantidad
Amount: USD 0.00
Please select quantity
or
or

* Seleccione Cantidad antes de agregar artículos.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
  • Actividad biológica
  • Chemical Information
  • Solvente y solubilidad
  • Pureza y Documentación
  • Referencias
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) H-151

More
Customer Validation & Images
IFWBCell Proliferation/Viability AssayRT-PCR
  • WB
  • Cell Proliferation/Viability Assay
  • WB
  • IF
  • WB
  • RT-PCR
Keywords
MOQ
Minimum order quantity
100 mg

Obtener un presupuesto En stock

Other size
Obtener un presupuesto
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Inicie sesiòn
Registrar
Sign in to MedChemExpress
Registrar una cuenta nueva

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • H-151 Chemical Structure
    H-151 Chemical Structure
    1/16
  • 1/16

    H-151 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Jun 18:e2401634. [Abstract]

    Customer Validation
     H-151 (750 nmol in 200 µL PBS with 5% Tween-80) suppresses radiation-induced phosphorylation of TBK1 and IRF3 in the colons of C57BL/6J mice.

  • 1/16

    H-151 purchased from MedChemExpress. Usage Cited in: Small. 2024 Mar;20(9):e2307448. [Abstract]

    Customer Validation
     H-151 (1-10 μM; 24 h) dose-dependently reduces 223Ra (3.7 kBq/mL; 48 h)-induced cytotoxicity in LLC cells.

  • 1/16

    H-151 purchased from MedChemExpress. Usage Cited in: Small. 2024 Mar;20(9):e2307448. [Abstract]

    Customer Validation
     H-151 (1 μM; 24 h) significantly attenuates 223Ra (3.7 kBq/mL; 48 h)-induced upregulation of NLRP3 expression while increasing the cleaved GSDMD/GSDMD ratio in LLC cells.

  • 1/16

    H-151 purchased from MedChemExpress. Usage Cited in: Toxicol Lett. 2023 Jan 15:373:172-183. [Abstract]

    Customer Validation
     H-151 (H151; 750 nM/mice; i.p.; every 12 h for 72 h) significantly restores inflammatory cell infiltration and ECM deposition in the mice with EsA (fig K), and decreases collagen fiber streaks (blue-stained area) (fig M).

  • 1/16

    H-151 purchased from MedChemExpress. Usage Cited in: Cell Metab. 2021 Oct 5;33(10):2076-2089.e9. [Abstract]

    Customer Validation
     FHs 74 Int cells were pretreated with 1 μM H-151 or 4 μM C-170 for 2 h and then exposed to 10 Gy ionizing radiation. IFNb expression was examined by qPCR 2 h after irradiation.

  • 1/16

    H-151 purchased from MedChemExpress. Usage Cited in: Cancer Res. 2021 May 15;81(10):2714-2729. [Abstract]

    Customer Validation
     RT-qPCR analysis of CCL5, CXCL10, ISG15 and IFI44 expression in HOC7 with depletion of STING by STING inhibition (1 μM H151) for 24 hours.

  • H-151