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Referencia número: HY-129236

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Hellebrin

Hellebrin is a bufadienolide compound extracted from plants that can inhibit tumor cell growth. Hellebrigenin shows potential in overcoming cancer cells' resistance to apoptosis stimuli and has also demonstrated anti-proliferation effects in multidrug-resistant (MDR) cancer cell models. Hellebrin can act on Na+/K+-ATPase to regulate intracellular signaling pathways.

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No. CAS: 13289-18-4
Fòrmula: C₃₆H₅₂O₁₅
Peso molecular:724.79

Almacenamiento:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Hellebrin Chemical Structure

No. CAS: 13289-18-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	16 nM Compound: hellebrin	Growth inhibition of human A549 cells after 72 hrs by MTT assay Growth inhibition of human A549 cells after 72 hrs by MTT assay	[PMID: 20361780]
A549	IC₅₀	6 nM Compound: 3a	Cytotoxicity against human A549 cells after 3 days by MTT assay Cytotoxicity against human A549 cells after 3 days by MTT assay	[PMID: 23706005]
B16-F10	IC₅₀	>10000 nM Compound: hellebrin	Growth inhibition of mouse B16F10 cells after 72 hrs by MTT assay Growth inhibition of mouse B16F10 cells after 72 hrs by MTT assay	[PMID: 20361780]
B16-F10	IC₅₀	>10000 nM Compound: 3a	Cytotoxicity against mouse B16F10 cells after 3 days by MTT assay Cytotoxicity against mouse B16F10 cells after 3 days by MTT assay	[PMID: 23706005]
CT26	IC₅₀	>10000 nM Compound: hellebrin	Growth inhibition of mouse CT26 cells after 72 hrs by MTT assay Growth inhibition of mouse CT26 cells after 72 hrs by MTT assay	[PMID: 20361780]
CT26.WT	IC₅₀	>10000 nM Compound: 3a	Cytotoxicity against mouse CT26.WT cells after 3 days by MTT assay Cytotoxicity against mouse CT26.WT cells after 3 days by MTT assay	[PMID: 23706005]
Hs 683	IC₅₀	7 nM Compound: hellebrin	Growth inhibition of human Hs683 cells after 72 hrs by MTT assay Growth inhibition of human Hs683 cells after 72 hrs by MTT assay	[PMID: 20361780]
Hs 683	IC₅₀	7 nM Compound: 3a	Cytotoxicity against human Hs683 cells after 3 days by MTT assay Cytotoxicity against human Hs683 cells after 3 days by MTT assay	[PMID: 23706005]
MCF7	IC₅₀	82 nM Compound: hellebrin	Growth inhibition of human MCF7 cells after 72 hrs by MTT assay Growth inhibition of human MCF7 cells after 72 hrs by MTT assay	[PMID: 20361780]
MCF7	IC₅₀	44 nM Compound: 3a	Cytotoxicity against human MCF7 cells after 3 days by MTT assay Cytotoxicity against human MCF7 cells after 3 days by MTT assay	[PMID: 23706005]
PC-3	IC₅₀	11 nM Compound: 3a	Cytotoxicity against human PC3 cells after 3 days by MTT assay Cytotoxicity against human PC3 cells after 3 days by MTT assay	[PMID: 23706005]
SK-MEL-28	IC₅₀	68 nM Compound: 3a	Cytotoxicity against human SK-MEL-28 cells after 3 days by MTT assay Cytotoxicity against human SK-MEL-28 cells after 3 days by MTT assay	[PMID: 23706005]
U-373MG ATCC	IC₅₀	49 nM Compound: hellebrin	Growth inhibition of human U373 cells after 72 hrs by MTT assay Growth inhibition of human U373 cells after 72 hrs by MTT assay	[PMID: 20361780]
U-373MG ATCC	IC₅₀	36 nM Compound: 3a	Cytotoxicity against human U373 cells after 3 days by MTT assay Cytotoxicity against human U373 cells after 3 days by MTT assay	[PMID: 23706005]

Chemical Information

No. CAS 13289-18-4
Appearance Solid
Peso molecular 724.79
Fòrmula C₃₆H₅₂O₁₅
Color White to off-white
SMILES

O=C1C=CC([C@H]2CC[C@@]3([C@@]4(CC[C@@]5(C[C@H](CC[C@@]5([C@]4(CC[C@]23C)[H])C=O)O[C@]6([C@H](O)[C@H](O)[C@@]([H])(O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@H](O7)CO)[C@@H](O6)C)[H])O)[H])O)=CO1
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
SDS (481 KB)
- English - EN (481 KB)
- Français - FR (481 KB)
- Deutsch - DE (481 KB)
- Norwegian - NO (481 KB)
- Español - ES (481 KB)
- Swedish - SV (481 KB)
- Italian - IT (481 KB)
- Korean - KR (481 KB)
- Portuguese - PT (481 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Laetitia Moreno Y Banuls, et al. Hellebrin and its aglycone form hellebrigenin display similar in vitro growth inhibitory effects in cancer cells and binding profiles to the alpha subunits of the Na+/K+-ATPase. Mol Cancer. 2013 Apr 26:12:33. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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