Immuno modulator-1
Immuno modulator-1 (compound 22) inhibits TNFα and IL-2 secretion in human peripheral blood mononuclear cells (hPBMC), with IC50 values of 4.7 and 26 nM, respectively. Immuno modulator-1 shows hERG potassium channel blocking effect, with Inhibitory percentage of 20% at 3 μM.
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- No. CAS: 2757469-20-6
- Fòrmula: C32H31FN6O4
- Peso molecular:582.62
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
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IL-2 |
In Vitro
Immuno modulator-1 (compound 22) inhibits the proliferation of NCI-H929 human myeloma cell, with an IC50 of 0.6 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats[1]
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Dosage:1 mg/kg (IV), 5 mg/kg (PO)
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Administration:IV (2 mL/kg), PO (10 mL/kg); once (Pharmacokinetic Analysis)
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Result:Pharmacokinetic Parameters of Immuno modulator-1 in male Sprague-Dawley rats[1].
IV (1 mg/kg) PO (5 mg/kg) Cmax (ng/mL) 1437 AUC0-24 (ng/mL∗h) 13029 CL (mL/min/kg) 2.2 Vss (L/kg) 0.36 F (%) 30%
Chemical Information
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No. CAS 2757469-20-6
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Peso molecular 582.62
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Fòrmula C32H31FN6O4
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SMILES
C[C@@H](N1CCN(C2=C(C=C(C=N2)C#N)F)CC1)C(C=C3)=CC=C3COC4=C5C(C(N([C@@H]6C(NC(CC6)=O)=O)C5)=O)=CC=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Immuno modulator-1 Related Classifications
HY-153952 Related Classifications
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