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Referencia número: HY-100849

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JAK 3i

2 Cited Publications

Revisión del cliente

Based on 2 publication(s) in Google Scholar

JAK3i is a highly selective JAK3 inhibitor (IC₅₀: 0.43 nM). JAK3i forms a covalent bond with a cysteine in JAK3, but not the closely related kinase domains in JAK1, JAK2, or TYK2. JAK3i abolishes IL-2-driven T-cell proliferation in vivo and has the potential for autoimmune disease research.

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Pureza: 99.81%
No. CAS: 1918238-72-8
Fòrmula: C₁₈H₁₅FN₄O₃
Peso molecular:354.34

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

JAK 3i Chemical Structure

No. CAS: 1918238-72-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
Chemical Information
Publications (2)
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Descripciòn

IC₅₀ & Target^[1]

JAK3

0.43 nM (IC₅₀)

JAK2

8680 nM (IC₅₀)

JAK1

1520 nM (IC₅₀)

Ver todos los productos específicos de isoformas JAK :

Chemical Information

No. CAS 1918238-72-8
Appearance Solid
Peso molecular 354.34
Fòrmula C₁₈H₁₅FN₄O₃
Color White to off-white
SMILES

CCOC(C1=CN=C2C1=C(C3=C(F)C=CC(NC(C=C)=O)=C3)NC=N2)=O
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Phytother Res

(+)-Matairesinol, Derived From Olive Oil, Enhanced T-Cell Anti-Tumor Immune via JAK3-STAT1 Signal and Synergized With Anti-PD-1 Efficacy. [Abstract]

2026 Apr 27. PMID: 42037203
J Ethnopharmacol

"Shihu" promote T-cell immunity against breast cancer through bioactive constituent THMB enhancing JAK3-STAT1 signal. [Abstract]

2026 Oct 28:369:121888. PMID: 42202911

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (273 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Geoffrey A Smith, et al. Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling. Nat Chem Biol. 2016 May;12(5):373-9. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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JAK 3i

2 Cited Publications

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Actividad biológica
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Publications (2)
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JAK 3i

Publications Citing Use of MedChemExpress (MCE) JAK 3i

Ver todos los productos específicos de isoformas JAK

Actividad biológica

Chemical Information

Publications (2)

Pureza y Documentación

Referencias

Calculators

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JAK 3i Related Classifications

HY-100849 Related Classifications