KKII5
Based on 1 Customer Validation
KKII5 is a potent Lipoxygenase (LOX-1) inhibitor with an IC50 of 19 μM. KKII5 inhibits lipid peroxidation.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.60%
- No. CAS: 6381-55-1
- Fòrmula: C16H14N2S
- Peso molecular:266.36
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
IC50: 19 μM (LOX-1)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
>10 μM
Compound: 5
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Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as inhibition of 5H-dibenzo[b,e]azepine-10-carboxylic acid methyl ester-induced increase in intracellular calcium by Fluo4-AM based fluorometric assay
Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as inhibition of 5H-dibenzo[b,e]azepine-10-carboxylic acid methyl ester-induced increase in intracellular calcium by Fluo4-AM based fluorometric assay
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[PMID: 22222037] |
KKII5 interacts with HIS499 of the cavity by forming one π–π stacking interaction between the phenyl ring of the molecule and the imidazole ring of HIS499[1].
KKII5 (100 μM) strongly inhibits lipid peroxidation with 98% inhibition[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 6381-55-1
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Appearance Solid
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Peso molecular 266.36
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Fòrmula C16H14N2S
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Color White to off-white
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SMILES
C1=CC=C(C=C1)C2C=C(NC(=S)N2)C3=CC=CC=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (375.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7543 mL | 18.7716 mL | 37.5432 mL | 93.8579 mL |
| 5 mM | 0.7509 mL | 3.7543 mL | 7.5086 mL | 18.7716 mL | |
| 10 mM | 0.3754 mL | 1.8772 mL | 3.7543 mL | 9.3858 mL | |
| 15 mM | 0.2503 mL | 1.2514 mL | 2.5029 mL | 6.2572 mL | |
| 20 mM | 0.1877 mL | 0.9386 mL | 1.8772 mL | 4.6929 mL | |
| 25 mM | 0.1502 mL | 0.7509 mL | 1.5017 mL | 3.7543 mL | |
| 30 mM | 0.1251 mL | 0.6257 mL | 1.2514 mL | 3.1286 mL | |
| 40 mM | 0.0939 mL | 0.4693 mL | 0.9386 mL | 2.3464 mL | |
| 50 mM | 0.0751 mL | 0.3754 mL | 0.7509 mL | 1.8772 mL | |
| 60 mM | 0.0626 mL | 0.3129 mL | 0.6257 mL | 1.5643 mL | |
| 80 mM | 0.0469 mL | 0.2346 mL | 0.4693 mL | 1.1732 mL | |
| 100 mM | 0.0375 mL | 0.1877 mL | 0.3754 mL | 0.9386 mL |
KKII5 Related Classifications
HY-W488004 Related Classifications
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