Kulinone
Based on 1 Customer Validation
Kulinone is a triterpenoid anticancer agent. Kulinone induces cytotoxic effects in lung cancer and gastric cancer cells. Kulinone is isolated from the bark of Melia azedarach. Kulinone is applicable to research related to lung cancer and gastric cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.75%
- No. CAS: 21688-61-9
- Fòrmula: C30H48O2
- Peso molecular:440.70
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BXPC-3 | GI50 |
3.61 μg/mL
Compound: 9
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Growth inhibition of human BxPC3 cells
Growth inhibition of human BxPC3 cells
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[PMID: 12502333] |
| DU-145 | GI50 |
3.6 μg/mL
Compound: 9
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Growth inhibition of human DU145 cells
Growth inhibition of human DU145 cells
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[PMID: 12502333] |
| KM-20L2 | GI50 |
3.6 μg/mL
Compound: 9
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Growth inhibition of human KM20L2 cells
Growth inhibition of human KM20L2 cells
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[PMID: 12502333] |
| MCF7 | GI50 |
3.6 μg/mL
Compound: 9
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Growth inhibition of human MCF7 cells
Growth inhibition of human MCF7 cells
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[PMID: 12502333] |
| MCF7 | IC50 |
42.5 μg/mL
Compound: 13
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Cytotoxicity against human MCF7 cells after 36 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 36 hrs by MTT assay
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[PMID: 20961091] |
| NCI-H460 | GI50 |
3.6 μg/mL
Compound: 9
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Growth inhibition of human NCI-H460 cells
Growth inhibition of human NCI-H460 cells
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[PMID: 12502333] |
| P388 | ED50 |
1.7 μg/mL
Compound: 13
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Cytotoxicity against mouse P388 cells
Cytotoxicity against mouse P388 cells
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[PMID: 20961091] |
| P388 | ED50 |
4.6 μg/mL
Compound: 9
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Growth inhibition of mouse P388 cells
Growth inhibition of mouse P388 cells
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[PMID: 12502333] |
| SF-268 | GI50 |
3.6 μg/mL
Compound: 9
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Growth inhibition of human SF268 cells
Growth inhibition of human SF268 cells
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[PMID: 12502333] |
| U2OS | IC50 |
6.9 μg/mL
Compound: 13
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Cytotoxicity against human U2OS cells after 36 hrs by MTT assay
Cytotoxicity against human U2OS cells after 36 hrs by MTT assay
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[PMID: 20961091] |
Chemical Information
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No. CAS 21688-61-9
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Appearance Solid
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Peso molecular 440.70
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Fòrmula C30H48O2
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Color White to off-white
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SMILES
C[C@@]12C3=CC[C@](C(C)(C(CC4)=O)C)([H])[C@@]4(C)[C@@]3([H])CC[C@]1([C@]([C@H](C2)O)([H])[C@H](C)CC/C=C(C)\C)C
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 50 mg/mL (113.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (2.84 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2691 mL | 11.3456 mL | 22.6912 mL | 56.7279 mL |
| 5 mM | 0.4538 mL | 2.2691 mL | 4.5382 mL | 11.3456 mL | |
| 10 mM | 0.2269 mL | 1.1346 mL | 2.2691 mL | 5.6728 mL | |
| 15 mM | 0.1513 mL | 0.7564 mL | 1.5127 mL | 3.7819 mL | |
| 20 mM | 0.1135 mL | 0.5673 mL | 1.1346 mL | 2.8364 mL | |
| 25 mM | 0.0908 mL | 0.4538 mL | 0.9076 mL | 2.2691 mL | |
| 30 mM | 0.0756 mL | 0.3782 mL | 0.7564 mL | 1.8909 mL | |
| 40 mM | 0.0567 mL | 0.2836 mL | 0.5673 mL | 1.4182 mL | |
| 50 mM | 0.0454 mL | 0.2269 mL | 0.4538 mL | 1.1346 mL | |
| 60 mM | 0.0378 mL | 0.1891 mL | 0.3782 mL | 0.9455 mL | |
| 80 mM | 0.0284 mL | 0.1418 mL | 0.2836 mL | 0.7091 mL | |
| 100 mM | 0.0227 mL | 0.1135 mL | 0.2269 mL | 0.5673 mL |
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