LBP-14
LBP-14, a peptide, is a synthetic fragment of the LPS (HY-D1056) binding protein (LBP) and is a LPS antagonist. LBP-14 interacts with LPS via electrostatic contacts between arginine/lysine residues and LPS phosphate groups, and hydrophobic contacts between aromatic/aliphatic residues and LPS acyl chains, blocking LPS binding to LBP. LBP-14 moderately inhibits LPS-induced TNF-α formation. LBP-14 can be used for the research of gram-negative sepsis.
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- No. CAS: 324030-22-0
- Fòrmula: C82H129N27O17
- Peso molecular:1765.07
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
LBP-14 (50 μM; 1 h preincubation, 4 h cell incubation) moderately inhibits LPS-induced TNF-α production in human buffy coat-derived PBMC[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 324030-22-0
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Peso molecular 1765.07
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Fòrmula C82H129N27O17
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Sequence
Arg-Val-Gln-Gly-Arg-Trp-Lys-Val-Arg-Ala-Ser-Phe-Phe-Lys
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Sequence Shortening
RVQGRWKVRASFFK
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LBP-14 Related Classifications
HY-P11772 Related Classifications
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