Lepidiline A
Based on 1 publication(s) in Google Scholar
Lepidiline A exhibits cytotoxic activity against HL-60 cells with an IC50 value of 32.3 μM. Lepidiline A targets HSD17B1 activity, increases the bioconversion efficiency of sex hormones (including the conversion of estrogen into 17β-estradiol and 4-androsten-3,7-dione into testosterone), thereby improving the reproductive capacity of fruit flies..
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- Pureza: 99.54%
- No. CAS: 596093-98-0
- Fòrmula: C19H21ClN2
- Peso molecular:312.84
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) Lepidiline A
MoreVer todos los productos específicos de isoformas 17β-HSD
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | ED50 |
>10 μg/mL
Compound: 1, lepidiline A
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Cytotoxicity against human A549 cells
Cytotoxicity against human A549 cells
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[PMID: 12932133] |
| HL-60 | IC50 |
32.3 μM
Compound: 1a
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Cytotoxicity against human HL-60 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Cytotoxicity against human HL-60 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
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[PMID: 34808062] |
| HT-29 | ED50 |
>10 μg/mL
Compound: 1, lepidiline A
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Cytotoxicity against human HT-29 cells
Cytotoxicity against human HT-29 cells
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[PMID: 12932133] |
| HUVEC | IC50 |
>100 μM
Compound: 1a
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Cytotoxicity against HUVEC cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Cytotoxicity against HUVEC cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
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[PMID: 34808062] |
| MCF7 | IC50 |
>100 μM
Compound: 1a
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Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
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[PMID: 34808062] |
| MDA-MB-231 | ED50 |
>10 μg/mL
Compound: 1, lepidiline A
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Cytotoxicity against human MDA231 cells
Cytotoxicity against human MDA231 cells
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[PMID: 12932133] |
| MIA PaCa-2 | ED50 |
>10 μg/mL
Compound: 1, lepidiline A
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Cytotoxicity against human MIAPaCa2 cells
Cytotoxicity against human MIAPaCa2 cells
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[PMID: 12932133] |
| PC-3 | ED50 |
>10 μg/mL
Compound: 1, lepidiline A
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Cytotoxicity against human PC3 cells
Cytotoxicity against human PC3 cells
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[PMID: 12932133] |
| UMUC3 | ED50 |
>10 μg/mL
Compound: 1, lepidiline A
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Cytotoxicity against human UM-UC-3 cells
Cytotoxicity against human UM-UC-3 cells
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[PMID: 12932133] |
Chemical Information
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No. CAS 596093-98-0
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Appearance Solid
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Peso molecular 312.84
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Fòrmula C19H21ClN2
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Color White to off-white
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SMILES
CC1=C(C)[N+](CC2=CC=CC=C2)=CN1CC3=CC=CC=C3.[Cl-]
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Solvente y solubilidad
DMSO : 62.5 mg/mL (199.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Mlostoń G, et al. Synthesis and Cytotoxic Activity of Lepidilines A-D: Comparison with Some 4,5-Diphenyl Analogues and Related Imidazole-2-thiones. J Nat Prod. 2021 Nov 22. [Content Brief]
[2]. Cheng C, et al. Lepidiline A Improves the Balance of Endogenous Sex Hormones and Increases Fecundity by Targeting HSD17B1. Mol Nutr Food Res. 2020 May;64(10):e1900706. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1965 mL | 15.9826 mL | 31.9652 mL | 79.9131 mL |
| 5 mM | 0.6393 mL | 3.1965 mL | 6.3930 mL | 15.9826 mL | |
| 10 mM | 0.3197 mL | 1.5983 mL | 3.1965 mL | 7.9913 mL | |
| 15 mM | 0.2131 mL | 1.0655 mL | 2.1310 mL | 5.3275 mL | |
| 20 mM | 0.1598 mL | 0.7991 mL | 1.5983 mL | 3.9957 mL | |
| 25 mM | 0.1279 mL | 0.6393 mL | 1.2786 mL | 3.1965 mL | |
| 30 mM | 0.1066 mL | 0.5328 mL | 1.0655 mL | 2.6638 mL | |
| 40 mM | 0.0799 mL | 0.3996 mL | 0.7991 mL | 1.9978 mL | |
| 50 mM | 0.0639 mL | 0.3197 mL | 0.6393 mL | 1.5983 mL | |
| 60 mM | 0.0533 mL | 0.2664 mL | 0.5328 mL | 1.3319 mL | |
| 80 mM | 0.0400 mL | 0.1998 mL | 0.3996 mL | 0.9989 mL | |
| 100 mM | 0.0320 mL | 0.1598 mL | 0.3197 mL | 0.7991 mL |
Lepidiline A Related Classifications
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