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Referencia número: HY-120931

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LY329146

LY329146, a Raloxifene (HY-13738) analog, is multidrug resistance protein (MRP1) inhibitor. LY329146 inhibits leucotriene C4 ( LTC4) transport with an IC₅₀ of 0.8 μM.

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No. CAS: 191043-78-4
Fòrmula: C₃₀H₃₂N₂O₇S₃
Peso molecular:628.78

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

LY329146 Chemical Structure

No. CAS: 191043-78-4

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- Cellular Effect
Chemical Information
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Actividad biológica

Descripciòn

LY329146, a Raloxifene (HY-13738) analog, is multidrug resistance protein (MRP1) inhibitor. LY329146 inhibits leucotriene C4 ( LTC4) transport with an IC₅₀ of 0.8 μM^[1].

Ver todos los productos específicos de isoformas Leukotriene Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	0.8 μM Compound: LY-329146	Inhibition of MRP1-mediated transport of [3H]LTC4 expressed in human HeLa T5 cells by liquid scintillation counting Inhibition of MRP1-mediated transport of [3H]LTC4 expressed in human HeLa T5 cells by liquid scintillation counting	[PMID: 19580319]
HL-60	IC₅₀	0.8 μg/mL Compound: LY-329146	Ability to inhibit 50 nM Leukotriene C4 (LTC4) uptake into HL60/ADR membrane vesicles Ability to inhibit 50 nM Leukotriene C4 (LTC4) uptake into HL60/ADR membrane vesicles	[PMID: 10612603]
HL60/ADR	IC₅₀	0.8 μM Compound: LY329146	TP_TRANSPORTER: inhibition of LTC4 uptake (LTC4: 0.5 uM) in membrane vesicles from HL60/ADR cells TP_TRANSPORTER: inhibition of LTC4 uptake (LTC4: 0.5 uM) in membrane vesicles from HL60/ADR cells	[PMID: 10612603]

Chemical Information

No. CAS 191043-78-4
Peso molecular 628.78
Fòrmula C₃₀H₃₂N₂O₇S₃
SMILES

CS(=O)(N(C1=CC=C(C2=C(C(C3=CC=C(OCCN4CCCCC4)C=C3)=O)C5=CC=C(O)C=C5S2)C=C1)S(=O)(C)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. H Sun, et al. Effect of probenecid on fluorescein transport in the central nervous system using in vitro and in vivo models. Pharm Res. 2001 Nov;18(11):1542-9. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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LY329146

Ver todos los productos específicos de isoformas Leukotriene Receptor

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

LY329146 Related Classifications

HY-120931 Related Classifications