MCTR3
Based on 1 Customer Validation
MCTR3 is a potent cytokine of pro-resolving mediating maresin conjugates in tissue regeneration (MCTR), which reduces the inflammatory response and promotes the tissue regeneration. MCTR3 exhibits potency in ameliorating LPS-induced acute lung injury and arthritis.
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- Pureza: 96.87%
- No. CAS: 1784701-63-8
- Fòrmula: C25H37NO5S
- Peso molecular:463.63
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Almacenamiento:
Solution, -20°C, 2 years
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Actividad biológica
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Chemical Information
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Help & FAQs
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Actividad biológica
MCTR3 (1 nM) alleviates LPS-induced cellular damage and oxidative stress, reduces apoptosis and autophagy-related protein production in cells MLE12 through the ALX/PINK1 pathway[1].
MCTR3 (1 nM) enhances efferocytosis and bacterial phagocytosis by exudate leukocytes, reduces neutrophil infiltration and eicosanoids[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MLE12
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Concentration:1 nM
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Incubation Time:24 h
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Result:Decreased LPS-stimulated expressions of PINK1 and Parkin.
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Cell Line:MLE12
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Concentration:1 nM
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Incubation Time:24 h
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Result:Decreased levels of Bax, Bak, Cyto C and LC3BII/I, increased levels of BCL2 and Bcl-xl.
MCTR3 (1-100 nM, in cold water) stimulates tissue regeneration in surgical injuried Planaria in a dose-dependent manner with a 50% tissue regeneration TRI50 of 2.5 days[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Lipopolysaccharide induced acute lung injury in C57BL6 mice[1]
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Dosage:2 ng/g
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Administration:i.p., single dose
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Result:Reduced inflammatory cell infiltration and protein accumulation in bronchoalveolar lavage fluid (BALF), reduced MDA levels and increased SOD activity in lung tissue.
Decreased levels of pro-inflammatory cytokine in serum.
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Animal Model:Surgical injury in Planaria[2]
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Dosage:1-100 nM
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Administration:In cold water for 6 days
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Result:Accelerated tissue regeneration in a dose-dependent manner with a TRI50 of 2.5 days.
Chemical Information
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No. CAS 1784701-63-8
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Appearance Liquid
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Peso molecular 463.63
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Fòrmula C25H37NO5S
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Color Colorless to light yellow
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SMILES
O[C@H]([C@@H](/C=C/C=C/C=C\C/C=C\CCC(O)=O)SC[C@@H](C(O)=O)N)C/C=C\C/C=C\CC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Solution, -20°C, 2 years
Pureza y Documentación
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Ficha de datos (267 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Zhuang R, et al., MCTR3 reduces LPS-induced acute lung injury in mice via the ALX/PINK1 signaling pathway. Int Immunopharmacol. 2021 Jan;90:107142. [Content Brief]
[2]. Dalli J et al., Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3. PLoS One. 2016 Feb 16;11(2):e0149319. [Content Brief]
[3]. Pistorius K, et al., MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis. EBioMedicine. 2022 May;79:103974. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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