Meldonium
Based on 5 publication(s) in Google Scholar
Meldonium (MET-88) functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2). Meldonium exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Meldonium is a fatty acid oxidation inhibitor.
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- Pureza: 99.90%
- No. CAS: 76144-81-5
- Fòrmula: C6H14N2O2
- Peso molecular:146.19
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Meldonium
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Customer Validation & Images
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Cell Migration/Invasion Assay
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Histological Imaging/Staining
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WB
Actividad biológica
Descripciòn
IC50 & Target
IC50: 34-62 μM (human recombinant BBOX).
EC50: 21 μM (human OCTN2).
In Vitro
Meldonium (20-40 μM; 24 h) ameliorates lung injury by targeting PFKP to regulate glycolysis, which promotes Nrf2 translocation from the cytoplasm to the nucleus to alleviate oxidative stress and mitochondrial damage under hypoxic condition[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Rat alveolar type II epithelial RLE-6TN cells in hypoxia incubator
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Concentration:20, or 40 μM
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Incubation Time:24 h
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Result:Significantly decreased the mRNA expression of PFKP, PDK1, and PKM2 compared with the hypoxia group.
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Cell Line:Rat alveolar type II epithelial RLE-6TN cells in hypoxia incubator
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Concentration:20, or 40 μM
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Incubation Time:24 h
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Result:Significantly reduced the protein expression of PFKP, PKM2, and LDHA.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 76144-81-5
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Appearance Solid
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Peso molecular 146.19
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Fòrmula C6H14N2O2
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Color White to off-white
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SMILES
C[N+](C)(C)NCCC([O-])=O
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Synonyms
MET-88; Quaterin
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (5)
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Journal Impact Factor
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Most Recent
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Nat Commun
2025 Feb 11;16(1):1543. PMID: 39934163
Meldonium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 11;16(1):1543. [Abstract]
Meldonium treatment of ccRCC cells attenuated the interaction between DCLK2 and BBOX1.
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Cell Rep Med
Targeting long-chain acylcarnitine accumulation to protect cardiac mitochondrial homeostasis after complete revascularization. [Abstract]2025 Dec 16;6(12):102507. PMID: 41406945 -
Neoplasia
BPGM as an intrinsic brake to constrain metastasis through phospho-epigenetic-mediated carnitine biosynthesis suppression. [Abstract]2026 May:75:101299. PMID: 41875824
Meldonium purchased from MedChemExpress. Usage Cited in: Neoplasia. 2026 May:75:101299. [Abstract]
Inhibition of BBOX1 reduced the migration ability of tumor cells. SNU-449 cells were treated with 100 mM Meldonium or PBS (vehicle) for 48 hours and then were employed to transwell assays.
Meldonium purchased from MedChemExpress. Usage Cited in: Neoplasia. 2026 May:75:101299. [Abstract]
Meldonium treatment decreased the lung metastatic foci in mice. 1 × 10^6 B16-F10 melanoma cells were injected into C57BL/6 mice via tail vein. Three days after tumor inoculation, the mice were administered intraperitoneal injections at a dosage of 70 mg/kg meldonium once every two days and were euthanized 17 days later.
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J Anim Sci
2022 Apr 1;100(4):skac069. PMID: 35247050 -
J Pharm Biomed Anal
Screening method of mildronate and over 300 doping agents by reversed-phase liquid chromatography-high resolution mass spectrometry. [Abstract]2021 Feb 20:195:113870. PMID: 33453569
Solvente y solubilidad
In Vitro:
H2O : 50 mg/mL (342.02 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (684.04 mM); Clear solution; Need ultrasonic
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Dambrova M, et al. Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmacol Res. 2016 Nov;113(Pt B):771-780. [Content Brief]
[2]. Jolanta Pupure, et al. Neuroprotective properties of mildronate, a mitochondria-targeted small molecule. Neurosci Lett. 2010 Feb 12;470(2):100-5. [Content Brief]
[3]. Daohui Wang, et al. Meldonium Ameliorates Hypoxia-Induced Lung Injury and Oxidative Stress by Regulating Platelet-Type Phosphofructokinase-Mediated Glycolysis. Front Pharmacol. 2022 Apr 5:13:863451. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.8404 mL | 34.2021 mL | 68.4041 mL | 171.0103 mL |
| 5 mM | 1.3681 mL | 6.8404 mL | 13.6808 mL | 34.2021 mL | |
| 10 mM | 0.6840 mL | 3.4202 mL | 6.8404 mL | 17.1010 mL | |
| 15 mM | 0.4560 mL | 2.2801 mL | 4.5603 mL | 11.4007 mL | |
| 20 mM | 0.3420 mL | 1.7101 mL | 3.4202 mL | 8.5505 mL | |
| 25 mM | 0.2736 mL | 1.3681 mL | 2.7362 mL | 6.8404 mL | |
| 30 mM | 0.2280 mL | 1.1401 mL | 2.2801 mL | 5.7003 mL | |
| 40 mM | 0.1710 mL | 0.8551 mL | 1.7101 mL | 4.2753 mL | |
| 50 mM | 0.1368 mL | 0.6840 mL | 1.3681 mL | 3.4202 mL | |
| 60 mM | 0.1140 mL | 0.5700 mL | 1.1401 mL | 2.8502 mL | |
| 80 mM | 0.0855 mL | 0.4275 mL | 0.8551 mL | 2.1376 mL | |
| 100 mM | 0.0684 mL | 0.3420 mL | 0.6840 mL | 1.7101 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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