Metconazole
Based on 1 Customer Validation
Metconazole is a 14α-demethylation inhibitor (DMI) fungicide. Metconazole inhibits fungal ergosterol biosynthesis, inhibits mycelial growth and conidial germ tube elongation. Metconazole reduces antioxidant enzyme activities. Metconazole reduces occurrence of Fusarium crown rot in wheat.
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- No. CAS: 125116-23-6
- Fòrmula: C17H22ClN3O
- Peso molecular:319.83
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Almacenamiento:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
In Vitro
Metconazole (0.001-0.1 μg/mL; 3 days) potently inhibits mycelial growth of 39 Fusarium pseudograminearum strains, with a mean EC50 value of 0.019 μg/mL[1].
Metconazole (0.05-0.2 μg/mL; 6-12 h) inhibits conidial formation, germination, and germ tube elongation of 39 Fusarium pseudograminearum strains[1].
Metconazole (0.02-0.2 μg/mL; 6 h) induces significant transcriptional changes in Fusarium pseudograminearum strain PY20-16, including upregulation of ergosterol biosynthesis genes and nine ABC transporter genes[1].
Metconazole (0.002-0.2 μg/mL; 7 days) at 0.02 and 0.2 μg/mL inhibits DON, 15-ADON, and ZEN production in Fusarium pseudograminearum strains CF1494 and PY20-16, while 0.002 μg/mL stimulates DON and 15-ADON production but still inhibits ZEN production[1].
Metconazole (0.05-0.2 μg/mL; 12 h) significantly reduces ergosterol production in Fusarium pseudograminearum strain PY20-16 in a dose-dependent manner[1].
Metconazole (0.05-0.2 μg/mL) significantly reduces catalase and peroxidase activities in Fusarium pseudograminearum mycelia[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Seeds (Jimai 19)[1]
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Dosage:0.06 μl AI/g seeds; 0.1 μl AI/g seeds; 0.14 μl AI/g seeds
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Administration:seed treatment
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Result:Achieved 32.79% control efficacy against Fusarium crown rot at 0.06 μl AI/g seeds.
Achieved 59.16% control efficacy against Fusarium crown rot at 0.1 μl AI/g seeds.
Achieved 77.24% control efficacy against Fusarium crown rot at 0.14 μl AI/g seeds.
Significantly reduced disease occurrence.
Chemical Information
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No. CAS 125116-23-6
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Unlabeled CAS 125116-23-6
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Appearance Solid
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Peso molecular 319.83
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Fòrmula C17H22ClN3O
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SMILES
ClC1=CC=C(C=C1)CC2CCC(C)(C)C2(O)CN3N=CN=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (312.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.82 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.82 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1267 mL | 15.6333 mL | 31.2666 mL | 78.1665 mL |
| 5 mM | 0.6253 mL | 3.1267 mL | 6.2533 mL | 15.6333 mL | |
| 10 mM | 0.3127 mL | 1.5633 mL | 3.1267 mL | 7.8167 mL | |
| 15 mM | 0.2084 mL | 1.0422 mL | 2.0844 mL | 5.2111 mL | |
| 20 mM | 0.1563 mL | 0.7817 mL | 1.5633 mL | 3.9083 mL | |
| 25 mM | 0.1251 mL | 0.6253 mL | 1.2507 mL | 3.1267 mL | |
| 30 mM | 0.1042 mL | 0.5211 mL | 1.0422 mL | 2.6056 mL | |
| 40 mM | 0.0782 mL | 0.3908 mL | 0.7817 mL | 1.9542 mL | |
| 50 mM | 0.0625 mL | 0.3127 mL | 0.6253 mL | 1.5633 mL | |
| 60 mM | 0.0521 mL | 0.2606 mL | 0.5211 mL | 1.3028 mL | |
| 80 mM | 0.0391 mL | 0.1954 mL | 0.3908 mL | 0.9771 mL | |
| 100 mM | 0.0313 mL | 0.1563 mL | 0.3127 mL | 0.7817 mL |
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