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Referencia número: HY-133760

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MI-888

MI-888 is an orally active MDM2 inhibitor with a K_i of 0.44 nM. MI-888 can inhibit the MDM2-p53 interaction. MI-888 has favorable pharmacokinetic properties and anti-tumor activity.

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No. CAS: 1303607-59-1
Fòrmula: C₂₈H₃₂Cl₂FN₃O₃
Peso molecular:548.48

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

MI-888 Chemical Structure

No. CAS: 1303607-59-1

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Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

MI-888 is an orally active MDM2 inhibitor with a K_i of 0.44 nM. MI-888 can inhibit the MDM2-p53 interaction. MI-888 has favorable pharmacokinetic properties and anti-tumor activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	>10 μM Compound: 9, MI-888	Cytotoxicity against p53-deficient human HCT116 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against p53-deficient human HCT116 cells assessed as growth inhibition by WST-8 assay	[PMID: 23786219]
HCT-116	IC₅₀	92 nM Compound: 9, MI-888	Cytotoxicity against human HCT116 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay Cytotoxicity against human HCT116 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay	[PMID: 23786219]
RS4-11	IC₅₀	0.06 μM Compound: 9, MI-888	Cytotoxicity against human RS4:11 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay Cytotoxicity against human RS4:11 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay	[PMID: 23786219]
SJSA-1	IC₅₀	0.08 μM Compound: 9, MI-888	Cytotoxicity against human SJSA1 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay Cytotoxicity against human SJSA1 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay	[PMID: 23786219]

Chemical Information

No. CAS 1303607-59-1
Peso molecular 548.48
Fòrmula C₂₈H₃₂Cl₂FN₃O₃
SMILES

CC(C)(C)C[C@H]1[C@]2(C3=CC=C(Cl)C=C3NC2=O)[C@@H](C4=C(C(Cl)=CC=C4)F)[C@@H](N1)C(N[C@H]5C[C@@](O)(C5)C)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Zhao Y, et al. A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice. J Med Chem. 2013 Jul 11;56(13):5553-61. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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