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Referencia número: HY-181804

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MRS8288

MRS8288 is a ABCG2 and P-glycoprotein inhibitor, with an IC₅₀ of 0.96 μM against ABCG2 and an IC₅₀ of 1.39 μM against P-glycoprotein. MRS8288 inhibits the ATPase activity of ABCG2 and P-glycoprotein, and suppresses ABCG2-mediated substrate transport. MRS8288 is applicable for cancer research.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₃₆H₂₈ClF₂N₉O₃
Peso molecular:708.12

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

MRS8288 Chemical Structure

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

In Vitro

MRS8288 (20 min) potently inhibits the basal ATPase activity of P-glycoprotein derived from High-Five insect cells, with an IC₅₀ of 1.39±0.20 μM^[1].
MRS8288 (20 min) potently inhibits the basal ATPase activity of ABCG2 derived from High-Five insect cells, with an IC₅₀ of 0.96±0.15 μM^[1].
MRS8288 (0-10 μM) potently inhibits ABCG2-mediated transport of Mitoxantrone (HY-13502) and Pheophorbide A (HY-125665) in HEK293-R5 cells, with IC₅₀ values of 2.49±0.16 μM and 4.86±0.4 μM, respectively^[1].
MRS8288 (72 h) exhibits cytotoxicity against both HEK293-pcDNA control cells and HEK293-R5 cells expressing ABCG2, with IC₅₀ values of 5.19±0.1 μM and 4.06±0.6 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Peso molecular 708.12
Fòrmula C₃₆H₂₈ClF₂N₉O₃
SMILES

O[C@@H]1[C@H](O)[C@](C(NC)=O)(C2)[C@H]2[C@H]1N(C=N3)C4=C3C(NCC5=CC=CC(N6N=NC(C7=CC=C(C=C7)Cl)=C6)=C5)=NC(C#CC8=CC=C(C(F)=C8)F)=N4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Murakami M, et al. (N)-Methanocarba Adenosine Derivatives as Dual Modulators of P-Glycoprotein and ABCG2 Transporters. J Med Chem. 2026;69(4):4945-4968. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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